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タイトル: Prognosis of asymptomatic endolymphatic hydrops in healthy volunteers: A five-year cohort study
その他のタイトル: 健康なボランティアの無症候性内リンパ水腫の予後:5 年のコホート研究
著者: Kimura, Takahiro
Kitahara, Tadashi
Okayasu, Tadao
Sakagami, Masaharu
Shiozaki, Tomoyuki
Inui, Hiroshi
Koizumi, Toshizo
Kakudo, Mariko
キーワード: asymptomatic endolymphatic hydrops
autonomic nervous dysregulation
depression
healthy controls
inner ear gadolinium-enhanced MRI
Meniere's disease
発行日: 2024年11月
出版者: Wiley
引用: Laryngoscope investigative otolaryngology. 2024 Nov, vol.9, no.6, e70026
抄録: Background: This study aimed to clarify the prognosis of asymptomatic endolymphatic hydrops (EH) in healthy volunteers via five-year follow-ups with inner ear magnetic resonance imaging (MRI). Methods: Inner ear MRI was performed on 115 participants recruited as controls in a previous study on Meniere's disease. The endolymphatic space was visualized using Naganawa's method of contrast-enhanced MRI with intravenous gadolinium injection and evaluated using Nakashima's method of 2D imaging analysis. Results: Cochlear or vestibular EH was present in 7.0% of participants (n = 8), with all cases being unilateral (laterality), moderate (severity), and asymptomatic (onset). Only cochlear-localized EH, only vestibular-localized EH, and both EH were present in 1.7% (n = 2) (C group), 4.3% (n = 5) (V group), and 0.9% (n = 1) (CV group) of participants, respectively. Conducting inner ear MRI after 5 years showed that EH had almost disappeared in two participants in the C and V groups (4/8, 50.0%). EH was still present in three participants in the V group and one in the CV group (4/8, 50.0%). One participant in the V group and another in the CV group presented with residual inner ear EH and developed typical symptomatic Meniere's disease (2/8, 25.0%). Conclusions: Approximately 7% of healthy participants showed asymptomatic EH. Therefore, EH is not the definitive marker for making a diagnosis of Meniere's disease or the suitable predictor for the development of Meniere's disease. Among these participants, 25% maintained EH and subsequently developed typical Meniere's disease within the next 5 years. Schellong-positive participants maintained persistent EH in the inner ear, and participants with higher scores on the self-rating depression scale developed Meniere's symptoms after 5 years.
内容記述: 権利情報:© 2024 The Author(s). Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/10564/4459
ISSN: 2378-8038
DOI: https://doi.org/10.1002/lio2.70026
学位授与番号: 24601甲第964号
学位授与年月日: 2025-03-14
学位名: 博士(医学)
学位授与機関: 奈良県立医科大学
出現コレクション:2024年度

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