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01 奈良県立医科大学 >
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0122 学位請求論文 >
01221 博士論文(医学) >
2024年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/4458
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タイトル: | Associations of demyelination in the right middle temporal gyrus and right praecuneus with visuospatial cognitive dysfunction in Alzheimer's disease |
その他のタイトル: | アルツハイマー病における視空間認知障害と右中側頭回および右楔前部の脱髄との関連 |
著者: | Ohnishi, Hiroki Matsuoka, Kiwamu Takahashi, Masato Yoshikawa, Hiroaki Minami, Akihiro Ueda, Kazuya Fujimoto, Yuka Kiuchi, Kuniaki Ochi, Tomoko Miyasaka, Toshiteru Tanaka, Toshihiro Matsumoto, Ryohei Makinodan, Manabu Okada, Takashi |
キーワード: | Alzheimer’s disease myelin T1-weighted/T2-weighted ratios visuospatial cognition |
発行日: | 2025年1月 |
出版者: | Japanese Psychogeriatrics Society |
引用: | Psychogeriatrics. 2025 Jan, vol.25, no.1, p.e13223 |
抄録: | Background: Alzheimer’s disease (AD) is associated with impairments in not only memory but also visuospatial cognitive function. Despite its
adverse effects on the quality of life, patients with early-stage AD are often neglected. Emerging evidence suggests that patients with AD exhibit
increased vulnerability of myelin, a crucial component for neuronal conduction and survival. To test our hypothesis that myelin damage was associated with cognitive deficits in AD, we examined correlations of myelin integrity, quantified by T1-weighted/T2-weighted (T1w/T2w) ratios, with visuospatial cognitive abilities and compared them between patients with AD and cognitively normal (CN) individuals.
Methods: Fifty-seven patients with AD and 22 CN subjects were enrolled in this study. To assess subjects’ visuo-constructive abilities, we employed
the Rey–Osterrieth Complex Figure Copy Test (ROCFT-c) paired with analysis of T1- and T2-weighted magnetic resonance imaging brain images. Voxel-based associations between T1w/T2w ratios and ROCFT-c scores in the AD group were assessed, controlling for age and handedness (voxel threshold uncorrected P < 0.001, cluster threshold uncorrected P < 0.05).
Additionally, we compared the T1w/T2w ratios of these identified brain regions between the AD and CN groups.
Results: The voxel-based analysis demonstrated positive correlations between T1w/T2w ratios and ROCFT-c scores in the right middle temporal gyrus and right praecuneus in patients with AD who exhibited significantly lower T1w/T2w ratios in the right middle temporal gyrus (P = 0.038) and a trend toward lower T1w/T2w ratios in the right praecuneus (P = 0.055).
Conclusions: Our results demonstrated a strong association between reduced myelin integrity in the right middle temporal gyrus and right praecuneus and visuospatial cognitive dysfunction in patients with
AD. These findings are believed to shed light on the neural basis of visuospatial processing in patients with AD, underlining the necessity for developing
objective biomarkers for assessing patients’ visuospatial cognitive function. |
内容記述: | 権利情報:© 2024 Japanese Psychogeriatric Society. |
URI: | http://hdl.handle.net/10564/4458 |
ISSN: | 1479-8301 |
DOI: | https://doi.org/10.1111/psyg.13223 |
学位授与番号: | 24601甲第963号 |
学位授与年月日: | 2025-03-14 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2024年度
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