DSpace DSpace Softwareについて English
 

GINMU >
01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2023年度 >

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/4359

タイトル: Synergistic effect of proteinuria on dipstick hematuria-related decline in kidney function: The Japan Specific Health Checkups (J-SHC) Study
その他のタイトル: 特定健診受診者を対象とした血尿に関連した腎機能低下に対する蛋白尿の相乗的な影響についての検証
著者: Tasaki, Hikari
Eriguchi, Masahiro
Yoshida, Hisako
Uemura, Takayuki
Fukata, Fumihiro
Nishimoto, Masatoshi
Kosugi, Takaaki
Matsui, Masaru
Samejima, Ken-Ichi
Iseki, Kunitoshi
Asahi, Koichi
Yamagata, Kunihiro
Konta, Tsuneo
Fujimoto, Shouichi
Narita, Ichiei
Kasahara, Masato
Shibagaki, Yugo
Moriyama, Toshiki
Kondo, Masahide
Watanabe, Tsuyoshi
Tsuruya, Kazuhiko
キーワード: eGFR Decline
Hematuria
Proteinuria
Sex differences
発行日: 2023年12月
出版者: Springer
引用: Clinical and Experimental Nephrology. 2023 Dec, vol.27, no.12, p.990-1000
抄録: Background: The effect of isolated hematuria without proteinuria on kidney function decline, and the modification by the severity of proteinuria in general population are not fully elucidated. Methods: Participants were included in the Japan Specific Health Checkups Study between 2008 and 2014. The exposure of interest was the frequency of dipstick hematuria during the observation. In each proteinuria frequency category (non-, occasional, persistent), hematuria-related decline in the eGFR rate was examined by analysis of covariance (ANCOVA). eGFR decline trajectories were also assessed using mixed-effects models. Results: Among the 552,951 participants, 146,753 (26.5%) had hematuria, and 56,021 (10.1%) and 8,061 (1.5%) had occasional and persistent proteinuria, respectively. During the median follow-up of 3.0 years, annual change in eGFR decline in participants with hematuria was significantly faster than in those without hematuria (mean [95% confidence interval]: - 0.95 [- 0.98 to - 0.92] vs - 0.86 [- 0.87 to - 0.84] mL/min/1.73 m2/year; P < 0.001). In ANCOVA, the hematuria-related annual eGFR decline rate increased as proteinuria frequency categories increased (differences in annual eGFR decline rate between participants with and without hematuria: 0.08 [0.06 to 0.09] in participants with non-proteinuria category, 0.17 [0.15 to 0.18] in occasional proteinuria category, and 0.68 [0.65 to 0.71] mL/min/1.73 m2/year in persistent proteinuria category; P for interaction < 0.001). Similar results were obtained by the linear mixed-effect model. Conclusions: Proteinuria has a synergistic effect on dipstick hematuria-related decline in kidney function. Among the general population without proteinuria throughout the observational period, the "isolated hematuria"-related eGFR decline was statistically significant but the difference was small.
内容記述: 権利情報:© The Author(s), under exclusive licence to Japanese Society of Nephrology 2023. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10157-023-02390-6
URI: http://hdl.handle.net/10564/4359
ISSN: 1342-1751
DOI: https://doi.org/10.1007/s10157-023-02390-6
学位授与番号: 24601甲第908号
学位授与年月日: 2024-03-14
学位名: 博士(医学)
学位授与機関: 奈良県立医科大学
出現コレクション:2023年度

このアイテムのファイル:

ファイル 記述 サイズフォーマット
01甲908本文.pdf甲908本文960.68 kBAdobe PDF見る/開く
02甲908本文の要旨.pdf甲908本文の要旨122.75 kBAdobe PDF見る/開く
03甲908審査要旨.pdf甲908審査要旨213.06 kBAdobe PDF見る/開く
04甲908Figure.pdf甲908Figure553.64 kBAdobe PDF見る/開く
05甲908Supplemental materials.pdf甲908Supplemental materials344.91 kBAdobe PDF見る/開く

このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。

 

Valid XHTML 1.0! Powered by DSpace Software Copyright © 2002-2007 MIT and Hewlett-Packard - ご意見をお寄せください