http://hdl.handle.net/10564/3965 2020-11 Fri, 10 Apr 2026 15:23:18 GMT 2026-04-10T15:23:18Z http://hdl.handle.net/10564/3971 タイトル: Two cases of Taeniasis Infection. 著者: Misu, Masayasu; Hirai, Nobuyasu; Kitamura, Tomotaka; Ouji, Yukiteru; Yoshikawa, Masahide; Kasamatsu, Takehito; Yoshihara, Shingo; Furukawa, Ryutaro; Nishimura, Tomoko; Okuda, Nao; Imakita, Natsuko; Fukumori, Tatsuya; Fujikura, Hiroyuki; Nishihara, Yuji; Sekine, Takahiro; Ogawa, Yoshihiko; Ogawa, Taku; Mikasa, Keiichi; Kasahara, Kei; Sato, Masatoshi; Maeda, Koichi 抄録: We report two cases of taeniasis caused by tapeworm infection. The first was a Japanese female, 23 years old, who had a history of eating raw meat during a visit to Thailand. She was referred to our hospital with a history of passing proglottids in feces. Taenia saginata or T. asiatica was suspected based on the proglottid morphologic features in addition to supportive information regarding her travel and dietary history. The patient was given praziquantel and the tapeworm was excreted. The second was a 35-year-old Thai male who had lived in Japan since 2000 and not left the country since that time. He had consumed beef cooked in the so-called yakiniku style and also sometimes raw, because of nostalgia for that Thai custom. The patient passed proglottids several times and then came to us. The proglottids were compatible with those of T. saginata. Praziquantel was prescribed and the tapeworm was excreted. In both cases, mitochondrial DNA analysis identified the worm species as T. saginata. Since morphological discrimination of three human-infecting Taenia species, T. saginata, T. solium, and T. asiatica, is not always possible, it is necessary to employ DNA analysis for diagnosis of taeniasis to confirm the worm species. Sun, 29 Nov 2020 15:00:00 GMT http://hdl.handle.net/10564/3971 2020-11-29T15:00:00Z http://hdl.handle.net/10564/3970 タイトル: Investigation of The Cause of Death in Inpatients with Dementia in Akitsu Konoike Hospital. 著者: Inoue, Keiichi; Kimoto, Sohei; Kitamura, Soichiro; Ko, Motoasa; Okamura, Kazuya; Hirai, Motoharu; Kishimoto, Toshifumi 抄録: The mortality rate of patients with dementia is known to be higher than that of the general population. Pneumonia is one of the most common causes of death in patients with dementia, and proper intervention is important for clinical outcomes. To date, it remains unclear whether there are differences in the risk factors of pneumonia among different types of dementia. Here, we investigated the primary cause of death in patients with dementia admitted at Akitsu Konoike Hospital. Furthermore, Cox regression analyses were performed to evaluate the risk factors associated with death by pneumonia among patients with Alzheimer's dementia (AD), vascular dementia (VaD), and other conditions. We found that pneumonia was one of the most common causes of death in all of the current samples. Additionally, poor outcomes were associated with the Barthel index in AD and aging or short disease duration in VaD. These results suggest that considering the diagnostic differences in death by pneumonia is important for clinical treatment of patients with dementia. Sun, 29 Nov 2020 15:00:00 GMT http://hdl.handle.net/10564/3970 2020-11-29T15:00:00Z http://hdl.handle.net/10564/3969 タイトル: 窒息急死死体解剖事例における血中アルコール濃度と軟凝血形成との関連について 著者: 中田, 匡俊; 工藤, 利彩; 勇井, 克也; 寺澤, 郁子; 羽竹, 勝彦; 粕田, 承吾 抄録: The fluidity of cadaveric blood is a major finding of asphyxial deaths. Although soft blood clots　are present in asphyxial cadaveric blood containing alcohol, only a few reports have statistically compared blood alcohol concentration (BAC) and soft blood clot formation. Using cadavers, German forensic pathologists found a positive correlation between BAC and the incidence of soft blood clots. Others found racial differences in sensitivity to ethanol due to polymorphisms in alcohol dehydrogenase and aldehyde dehydrogenase. We therefore set a low cutoff value (BAC>0.1mg/ml) and reexamined cases of asphyxial death-with or without ethanolin cadaveric blood obtained from Japanese cadavers. We divided 150 autopsy cases into two groups based on the cause of death: asphyxial deaths (n=74) and others (n=76).There were no significant between group differences in BAC; however, patients with asphyxial death exhibited significantly increased soft blood clot formation. When we divided the asphyxial group by BAC, there were 17 cases with BAC>0.1 and 57 cases with BAC=0mg/l. Soft blood clot formation was significantly increased in the BAC>0.1 group. Even a very low BAC is correlated with soft blood clot formation. Alcohol consumption should be considered if a soft blood clot is seen during autopsy. Sun, 29 Nov 2020 15:00:00 GMT http://hdl.handle.net/10564/3969 2020-11-29T15:00:00Z http://hdl.handle.net/10564/3968 タイトル: 血糖自己測定用ランセットによる自己採取血を利用した血中コルチゾール測定法の確立とその臨床応用 著者: 前原, 佳代子; 佐藤, 勝紀; 上嶋, 昌和; 榑松, 由佳子; 吉治, 仁志; 岡本, 新悟 抄録: Adrenal insufficiency is caused by either primary adrenal failure or by hypothalamic-pituitary impairment. Glucocorticoid replacement therapy in patients with adrenal insufficiency is lifesaving. However, the patients usualy need to visit or be admitted to hospital for monitoring of the temporal pattern of the cortisol level, which is required for the diagnosis and evaluation of the optimal glucocorticoid replacement. To reduce the burden on the patient and to assess the pattern of cortisol level in the patient's daily life, we subjected self-collected blood to the cortisol measurement using a DetectX® Cortisol Enzyme Immunoassay Kit. The new measurement was evaluated by comparison with an established in vitro diagnostic Cortisol Ⅱ that has been introduced in hospitals. Bland-Altman analysis was used for assessing the degree of agreement between two measurements by studying the mean difference and configuring limits of agreement. The bias (mean difference) was 20.01%. This bias was significant, because the line of equality (0%) was not in the confidence interval of the bias. The 95% limits of agreement were from - 55.71 to 95.74%. Although the cortisol values obtained with Cortisol Ⅱ were 1.450μg/dL higher on average than those obtained with DetectX, the measurements of DetectX correlated with those obtained with Cortisol Ⅱ. Therefore, we conducted cortisol measurement using blood self-collected by patients at home. Plasma cortisol levels in a patient with hypopituitarism responded to administration of hydrocortisone in a dose-dependent manner A patient who had been diagnosed with depressive disorder did not show the natural cortisol circadian rhythm. Low levels of cortisol during the morning seemed to be a cause of the reduced arousal level. We concluded that the measurement of cortisol using self-colected blood was useful for determining optimal glucocorticoid replacement therapy and screening for adrenal insufficiency. Sun, 29 Nov 2020 15:00:00 GMT http://hdl.handle.net/10564/3968 2020-11-29T15:00:00Z