http://hdl.handle.net/10564/3352 2016-12 Thu, 09 Apr 2026 03:56:21 GMT 2026-04-09T03:56:21Z http://hdl.handle.net/10564/3359 タイトル: 術前CTにて診断しえた膀胱ヘルニアの3例 著者: 中辻, 直之; 八倉, 一晃; 越智, 祥隆 抄録: We report 3 cases of bladder hernia　diagnosed by abdominal computed tomography (CT) preoperatively. Case 1: An 85-year-old male visited us due to right inguinal swelling. He had been treated for right indirect inguinal hernia by McVay repair procedure 21 years ago. CT confirmed that the hernia content was a part of the bladder. Case 2: A 63-year-old male visited us due to bilateral inguinal swelling. CT revealed a right inguinal hernia and a left bladder hernia. Case 3: A 64-year-old male visited us due to right inguinal swelling and a lower urinary tract symptom (two-phase micturition). CT showed the herniation of the bladder into the right inguinal region. Hernia repair was performed using a mesh plug procedure in the 3 cases. Fri, 30 Dec 2016 15:00:00 GMT http://hdl.handle.net/10564/3359 2016-12-30T15:00:00Z http://hdl.handle.net/10564/3358 タイトル: Minimum Ten-Year Follow-UP of Computed Tomography Based, Custom Cementless Stem After Intertrochanteric Osteotomy for Dysplastic Hips. 著者: Masuda, Yoshihide; Kawate, Kenji; Ohmura, Tetsuji; Munemoto, Mitsuru; Uchihara, Yoshinobu; Tanaka, Yasuhito 抄録: Background: During fixation of total hip arthroplasty (THA) after osteotomy, it is difficult to obtain a good cement mantle with a cemented stem and to obtain good fit along the medullary canal with a ready-made stem. We developed a CT-based custom stem, which was inserted after osteotomy in THA. Methods: We investigated 32 hips in 28 patients. The mean patient age at surgery was 62 and the mean follow-up period was 13 years. The previous osteotomy was intertrochanteric varus femoral osteotomy in 14 hips, intertrochanteric valgus femoral osteotomy in 17, and Schanz osteotomy in one. CT studies were obtained with a 5 mm slice intervals and 2 mm slice width. We produced stems made of Ti-6Al-4V. The stems did not have collars and the proximal third was coated with a 400-μ. m-thick porous coating covered with 20-μ m-hydroxyapatite (HA) coating. Results: The Harris Hip Score improved from a preoperative mean of 49.9 points to a postoperative mean of 82.7 points. One patient complained of postoperative thigh pain. Fractures occurred in two hips. Dislocation occurred in three patients. To date. no patient has reqired revision of the stem due to aseptic loosening. There was bone-ingrown fixation in all hips. Severe stress shielding was found in 14 hips (44%) Conclusion: Stable fixation was achieved with the proximal press-fit of the custom stem. Although stress shielding was observed in 14 hips, excellent results were obtained over a follow-up period of 10 years with this custom stem system for hips after intertrochanteric femoral osteotomy. 内容記述: 博士（医学）・乙第1419号・平成30年6月27日 Fri, 30 Dec 2016 15:00:00 GMT http://hdl.handle.net/10564/3358 2016-12-30T15:00:00Z http://hdl.handle.net/10564/3357 タイトル: Rehabilitation Using 13-Degree Forward Bending Poles for Patients with Rheumatoid Arthritis After a Total Joint Replacement. 著者: Ono, Seiichi; Suzuki, Sadahiro; Urano, Fusazo; Maruyama, Masaaki; Kawate, Kenji; Tanaka, Yasuhito 抄録: Here we evaluate the usefulness of 13-degree forward bending pole-assisted walking to promote the early discharge of rheumatoid arthritis patients after a total joint arthroplasty. We evaluated two male and six female rheumatoid arthritis patients with an average age of 64 who received a total hip or knee arthroplasty. We required them to perform pole-assisted walking five times a week for 20 minutes a day. Rehabilitation lasted 4-6 weeks until discharge. Clinical follow-up included mobility, physical strength and flexibility assessments. After 1 year of pole-assisted walking, two patients can play golf without the assistance of a cane. Patients who performed pole-assisted walking improved their walking speed 1 year after surgery by 5 seconds compared with speeds measured 4 weeks after surgery. Chair stand repetitions also increased over that time. Pole-assisted walking improved the stability and safety of the ambulation of rheumatoid arthritis patients after surgery. Patients also reported improved arm and leg strength. No falls were reported 5 years after surgery. This clinical trial is thought to be specific to patients with severe pain in many joints including knees and hips. Fri, 30 Dec 2016 15:00:00 GMT http://hdl.handle.net/10564/3357 2016-12-30T15:00:00Z http://hdl.handle.net/10564/3356 タイトル: Role of CD10 in the Metastasis of Colorectal Cancer to the Liver. 著者: Fujii, Kiyomu; Ohmori, Hitoshi; Fujiwara-Tani, Rina; Luo, Yi; Nishiguchi, Yukiko; Kishi, Shingo; Sasaki, Takamitsu; Kuniyasu, Hiroki 抄録: CD10 is a widely expressed endopeptidase that is present in human colorectal cancer (CRC), which shows a high frequency of liver metastasis. CD10 expression in CRC cells is associated with liver metastasis in rodent models, and CD10 expression enhances the phosphorylation of epidermal growth factor (EGF) receptor (EGFR) and extracellular signalregulated kinase (ERK) l/2. Met-enkephalin (MENK), a CD10 substrate, activates its specific receptor δ-opioid receptor (DOR), which is expressed in CRCs. DOR is a partial agonist of ERK1/2, which suppresses EGF-induced phosphorylation of EGFR and ERK1/2. CD10 retains EGF-induced EGFR activation by degrading MENK. Paradoxically, CRCs express MENK at a high frequency. Since MENK suppresses T lymphocytes, CD10-expressing CRCs can escape from T-cell immunity without exhibiting auto-inhibition. CD10 is strongly associated with the metastasis of CRCs to the liver via an immunosuppressive mechanism. Additionally, CD10 may be an excellent serum marker for liver metastasis in patients with CRC and could represent a potential molecular target for antimetastatic treatment in patients with CRC. Fri, 30 Dec 2016 15:00:00 GMT http://hdl.handle.net/10564/3356 2016-12-30T15:00:00Z