http://hdl.handle.net/10564/3262 2015-12 Fri, 10 Apr 2026 15:23:14 GMT 2026-04-10T15:23:14Z http://hdl.handle.net/10564/3267 タイトル: 第135回奈良医学会 : 学会記事 Wed, 30 Dec 2015 15:00:00 GMT http://hdl.handle.net/10564/3267 2015-12-30T15:00:00Z http://hdl.handle.net/10564/3266 タイトル: Early Removal of the Prophylactic Drain After Distal Gastrectomy : Results of a Randomized Controlled Study. 著者: Migita, Kazuhiro; Takayama, Tomoyoshi; Matsumoto, Sohei; Wakatsuki, Kohei; Tanaka, Tetsuya; Ito, Masahiro; Nakajima, Yoshiyuki 抄録: Background: The optimal timing of the drain removal after gastrectomy has been unclear. The aim of this prospective randomized controlled study was to assess the optimal timing of removal of prophylactic drains after distal gastrectomy (DG) or pylorus-preserving gastrectomy (PPG). Methods: All patients undergoing DG or PPG for gastric cancer were eligible for this study. The exclusion criteria were combined organ resection, the use of postoperative anticoagulant therapy, intraoperative injury of other organs and anastomotic problems. Just after the operation, the eligible patients were randomly assigned to either the early removal group (n=50), where the drain was removed in the morning of the postoperative day (POD) 1, or the control group (n=50), where the drain was removed on POD 3 or later. We compared the surgical outcomes between the groups. Results: The rate of overall postoperative complications was 18% in the early removal group and 18% in the control group, with no significant difference between the groups. The severity of complications was also similar between the groups. There were no significant differences between the groups with regard to the postoperative recovery, pain or the length of the postoperative hospital stay. Conclusions: The present study demonstrated the safety and feasibility of the early removal of prophylactic drains in selected patients undergoing DG or PPG for gastric cancer. Wed, 30 Dec 2015 15:00:00 GMT http://hdl.handle.net/10564/3266 2015-12-30T15:00:00Z http://hdl.handle.net/10564/3265 タイトル: 卒前教育における医学教育改革の成果についての卒業生アンケート調査 著者: 藤本, 眞一 抄録: Purpose and methods: To investigate the effects of reformation of pre-graduate medical education on the students of years 2005-2007, we analyzed a questionnaire targeting those students after graduation. Results: General education has a low degree of usefulness for the students. Basic medical education was useful as a preparation for clinical medicine. Clinical education was useful in terms of knowledge and skill, but not in terms of attitude. Both general education and clinical education were somewhat useful for the older graduates. Among the new educational methods, only OSCE was useful. Conclusion: Reformation of pre-graduate medical education was useful especially in regard to clinical skill education. Wed, 30 Dec 2015 15:00:00 GMT http://hdl.handle.net/10564/3265 2015-12-30T15:00:00Z http://hdl.handle.net/10564/3264 タイトル: Significance of Trans Fatty Acids in Cancer. 著者: Ohmori, Hitoshi; Fujii, Kiyomu; Kuniyasu, Hiroki 抄録: Trans fatty acids (TFAs) are a recent focus of health problems. TFA is a definitive risk factor for cardiovascular diseases and the death. TFA is also possible risk factor for Alzheimer's disease, obesity, diabetes, fatty liver, and ovulation infertility. The relationship between TFA and carcinogenic risk is controversial; however, TFA is reported to increase the risk of breast cancer and prostate cancer. Elaidic acid (EA), a trans form of oleic acid, enhances cancer cell growth, invasion, and anti-apoptotic survival. In animal models, EA promotes tumor growth and metastasis to the lung, liver, and peritoneum. EA induces sternness in cancer cells through transactivation of EFGR via SRC from GPR40/120 as receptors in EA-integrated cholesterol rafts. Activated EGFR relays the signals to activate canonical and non-canonical wnt pathways and to inactivate notchl pathways. EA also increases miR-494, which inhibits cell differentiation through decrease of target genes. Continuous EA feeding with dosage alteration increased cancer cell sternness. EA diminishes the efficiency of 5-fluorouracil by increasing residual cancer stem cells. These findings suggest that TFA is a relevant cancer promoting factor. The decision to remove TFA from foods made by the FDA might have an impact on cancer clinics. Wed, 30 Dec 2015 15:00:00 GMT http://hdl.handle.net/10564/3264 2015-12-30T15:00:00Z