http://hdl.handle.net/10564/2605 2012-12 Thu, 09 Apr 2026 03:49:18 GMT 2026-04-09T03:49:18Z http://hdl.handle.net/10564/2610 タイトル: 平成24年度特別講演事業(先端医学研究機構)「ヌクレオチド除去修復の機構と遺伝疾患」 著者: 田中, 亀代次; 森, 俊雄 Sun, 30 Dec 2012 15:00:00 GMT http://hdl.handle.net/10564/2610 2012-12-30T15:00:00Z http://hdl.handle.net/10564/2609 タイトル: SIGNIFICANCE OF ANGIOTENSIN SYSTEM IN PROGRESSION OF COLORECTAL CANCER 著者: Luo, Yi; Shimomoto, Takasumi; Kuniyasu, Hiroki 抄録: Colorectal cancer (CRC) cells possess an angiotensin activation mechanism provided by the expression of renin and chymase. Renin expression is induced by hyperglycemic condition. Since angiotensinogen is produced in the liver, CRC cells with angiotensin-activating machinery possess an advantage to metastasize to the liver. In human CRC cases, the diabetes complicated patients show higher concentrations of renin, angiotensin-Ⅱ in the primary tumors, and more progressed disease stage, especially, liver metastasis in an association with HbA1c levels than those in the patients without diabetes. Concurrent treatment with anti-angiotensin and hypoglycemic agents shows a synergic effect of decrease of liver metastasis and improvement of the survival of diabetic mice of CRC liver metastasis model. The effect of anti-angiotensin treatment and blood sugar control as a baseline management of the colon cancer patients with the diabetic condition is needed to be examined in clinical situation for prevention of liver metastasis. Sun, 30 Dec 2012 15:00:00 GMT http://hdl.handle.net/10564/2609 2012-12-30T15:00:00Z http://hdl.handle.net/10564/2608 タイトル: 上部胃癌に対する胃上部郭清を先行した腹腔鏡下胃切除術の定型化 著者: 高山, 智燮; 松本, 壮平; 若月, 幸平; 田仲, 徹行; 右田, 和寛; 伊藤, 眞廣; 中島, 祥介 抄録: In the present report, we show the standardizing laparoscopic procedure for proximal early gastric cancer, in which the dissection of upper portion of the stomach precedes the transection of duodenum or distal side of the stomach. First, the lesser omentum is opened toward the esophagus, and the right side of abdominal esophagus and the right crus of diaphragm are exposed. Then, the greater omentum is opened, and the left gastroepiploic vessels are divided. In the same view, the short gastric vessels are continued to dividing and the left side of the abdominal esophagus is exposed. Next, the pancreatic capsule is dissected along the common hepatic artery and splenic artery. Lymph node dissection of station No. 8a, 9, 11p can be achieved. The left gastric artery is divided with preservation of the celiac branch of the vagus nerve. Finally, the transection of the abdominal esophagus is performed. Consequently, the dissection of upper portion of the stomach is completed and the stomach is extracted from minilaparotomy. In case of total gastrectomy, the dissection of supra- and infrapyloric lymph nodes and the transection of duodenum lastly performed. The standardization of dissecting procedure in laparoscopy-assisted total gastrectomy and function-preserving gastrectomy, including proximal gastrectomy and pylorus-preserving nearly total gastrectomy, has made possible the safety of laparoscopic surgery for proximal gastric cancer. Sun, 30 Dec 2012 15:00:00 GMT http://hdl.handle.net/10564/2608 2012-12-30T15:00:00Z http://hdl.handle.net/10564/2607 タイトル: 食道癌に対する低侵襲手術と成績向上への取り組み ： 開胸手術から鏡視下手術(VATS-E)へ 著者: 田仲, 徹行; 高山, 智燮; 松本, 壮平; 若月, 幸平; 右田, 和寛; 伊藤, 眞廣; 中島, 祥介 抄録: In this study we investigated the advantages of video-assisted thoracoscopic surgery for esophageal cancer (VATS). From 2001 to 2011, 110 cases were operated on for esophageal cancer in our department. We classified these cases into three groups : a conventional open surgery group (OS) (70 cases), a first half group (20 cases) for VATS and a second-half group (20 cases) for VATS (40 cases). There were no significant differences among the three groups in terms the patient characteristics and states of tumors. Operation times were long in the VATS groups than in the OS group. On the ohter hand, intraoperative blood loss was significantly less and the number of dissected lymph nodes was significantly increased in second-half group for VATS when compared with OS group. The incidence of all postoperative complications was significantly lower in the second-half group for VATS than in the OS group, especially those relating to the respiratory system. As a resutlt, the duration of ICU stay and postoperative hospital stay was shortened in the second-half group. We thought that the expansion effect of viewing with VATS brought about the reduction in the rate of complications and shortening of duration of hospitalization, due to the exact preservation of the vagus branch of the pulmonary plexus, recurrent laryngeal nerve or bronchial artery. Mastery of VATS is required to obtain these benefits. Sun, 30 Dec 2012 15:00:00 GMT http://hdl.handle.net/10564/2607 2012-12-30T15:00:00Z