http://hdl.handle.net/10564/2025 1990-10 Thu, 09 Apr 2026 03:46:37 GMT 2026-04-09T03:46:37Z http://hdl.handle.net/10564/2046 タイトル: 胎生期ヒト脳，特にsecond trimesterの時期におけるMRIに関する研究 著者: 渡部, 安晴 抄録: Magnetic resonance (MR) images were compared with histological and anatomical observations in 31 fetuses ranging from 10 to 25 weeks gestation to study the relationship between MR images and the development of the neopallium during the second trimester. T1 weighted MR images and T2 weighted MR images taken within 8 hours after delivery were compared with H. E. stained histological slices. On T1 weighted MR images after 18 weeks gestation, the neopallium consisted of four layers which appeared as areas of high, relatively high, low and high signal intensity, respectively, from the ventricular side to the brain surface. These layers corresponded to the ventricular zone, the subventricular zone, the intermediate zone and the cortical plate respectively. On T2 weighted images, these areas appeared only as three layers of low, relatively low and high signal intensity, respectively, from the ventricular side, and the most lateral layer was not distinct from the adjacent layer. Beyond 14 weeks gestation, the ganglionic eminence showed almost the same signal intensity as the ventricular zone. The visualization of the primary fissures by MR images was compared with reported anatomical studies in all fetuses, and with anatomical sections from 18 fetuses. These studies revealed little variation in the time of the first appearance of primary fissures, except that there was a few weeks delay on MR imaging (MRI) of mesially located fissures. Thus MRI was confirmed to be useful in estimating the development of the fetal brain on the basis of imaging of the laminal structures of the neopallium and the appearance of primary fissures. Tue, 30 Oct 1990 15:00:00 GMT http://hdl.handle.net/10564/2046 1990-10-30T15:00:00Z http://hdl.handle.net/10564/2045 タイトル: A NEW OPERATIVE TECHNIQUE FOR ESOPHAGEAL RECONSTRUCTION USING A LONG GASTRIC TUBE OF 3 CM DIAMETER 著者: Nakatani, Katsunori; Okumura, Tohru; Watanabe, Akihiko; Nishiwada, Takashi; Sawada, Hidetomo; Yamada, Yoshiki; Yamada, Yukishige; Yano, Tomoaki; Shino, Yoshihide; Ueyama, Naoto; Nakano, Hiroshige 抄録: The anthors have successfully prepared a 3 cm diameter gastric tube with a more favorable blood supply than the conventional one by performing interrupted suture each of the mucosal layers and seromuscular layers of the stomach separately with pyloromyotomy as a drainage procedure. This gastric tube caused no clavicular pressure on the anastomotic portion through a retrosternal route, so that we could perform end-to-end anastomosis between the cervical esophagus and the gastric tube in a region higher than the clavicle. We report in this paper the clinical findings of our procedure : it was effective in preventing postoperative complications such as suture insufficiency and passage disturbance other than postoperative complaints due to dumping and reflux esophagitis, etc. Tue, 30 Oct 1990 15:00:00 GMT http://hdl.handle.net/10564/2045 1990-10-30T15:00:00Z http://hdl.handle.net/10564/2044 タイトル: 急性熱性皮膚粘膜リンパ節症候群(MCLS)におけるプロテインCおよびプロテインSの推移について 著者: 今中, 康文 抄録: Plasma levels of protein C (PC) and protein S (PS) were investigated in 34 children with mucocutaneous lymphnode syndrome (MCLS). These patients were categorized into two groups :, Group A, aged from 3 months to less than 1 year, and Group B, from 1 year to 14 years. In the first week of the acute stage of the clinical course, both levels of PC activity (PC : Act) assayed by A-PTT using PC-immunodepleted plasma, and Protac®, and PC antigen (PC : Ag) assayed by ELISA, were markedly decreased ; Group A, 42.0±13.8 U/dl and 51.9±20.5 U/dl, and Group B, 51.4±19.5 U/dl and 68.2±18.6 U/dl, respectively. The values gradually returned to normal range after 3-5 weeks of the clinical course. Similarly, levels of PS activity (PS : Act) assayed by A-PTT using PS-immunodepleted plasma and Protac®, total PS antigen (T-PS : Ag) and PS antigen complexed with C4b-binding protein (C4bp-S : Ag) assayed by ELISA were significantly decreased in the first week of the clinical course ; Group A, 52.2±11.7 U/dl, 62.0±12.0 U/dl and 53.0±15.4 U/dl, and Group B, 73.6±14.7 U/dl, 82.4±16.5 U/dl and 78.8±21.3 U/dl. They were restored to normal range within the following one to 4 weeks. Free-PS antigen (F-PS : Ag) levels in both groups were almost normal or slightly decreased during the first week of the clinical course ; Group A, 71.7±15.6 U/dl and Group B, 75.8±22.4 U/dl. No precursor forms of PC : Ag and PS : Ag (PIVKAs-PC and -PS) were detected by crossed immunoelectrophoresis. Neither PC levels nor PS levels showed a significant difference between the patients with and without coronary aneurysm, whereas the former patients required 1-2 weeks longer to restore the lowered plasma levels than the latter. These results indicate that the duration of the decreased levels of plasma PC and PS is important to assess the development of anticipated thromboembolic complications in MCLS. Tue, 30 Oct 1990 15:00:00 GMT http://hdl.handle.net/10564/2044 1990-10-30T15:00:00Z http://hdl.handle.net/10564/2043 タイトル: von Willebrand因子(vWF)のヒトType Ⅲ collagenへの結合に関する研究 ： Ⅱ. von Willebrand病および血友病A患者血漿中のvWFのcollagen結合 著者: 西久保, 敏也 抄録: The percentage of binding of vWF to human Type Ⅲ fibrillar collagen was determined in plasma samples from 20 patients with various types of von Willebrand disease (vWD) and 27 patients with hemophilia A. The levels of collagen binding were normal, ranging from 83.6 to 90.0% in 9 cases of Type 1 vWD. In 7 cases of Type ⅡA vWD and 3 cases of Type ⅡB vWD, the rates of collagen binding were 42.0～76.1% and 68.0～80.0% respectively. A case of Type ⅡC vWD showed a remarkable decrease, with 35.8%. On the other hand, 27 cases of hemophilia A showed normal values with 91.0～98.7%. When plasma samles absorbed with collagen and then vWF multimer in the supernatant were analysed by agarose-gel electrophoresis, the larger multimer of normal vWF showed the strongest affinity to collagen, while the smallest one was poor. Changes of vWF multimer in Type Ⅰ vWD showed the same results as those of normal plasma, but Types ⅡA, ⅡB and ⅡC vWD showed a decreased affinity of intermediate and smaller multimer to collagen. These findings suggest that the poor affinity of vWF of Types ⅡA, ⅡB and ⅡC vWD to collagen may be caused by abnormality of the collagen binding domain in vWF subunit. Tue, 30 Oct 1990 15:00:00 GMT http://hdl.handle.net/10564/2043 1990-10-30T15:00:00Z