http://hdl.handle.net/10564/2014 1990-12 Fri, 10 Apr 2026 15:23:18 GMT 2026-04-10T15:23:18Z http://hdl.handle.net/10564/2024 タイトル: 第111回奈良医学会 : 学会記事 Sun, 30 Dec 1990 15:00:00 GMT http://hdl.handle.net/10564/2024 1990-12-30T15:00:00Z http://hdl.handle.net/10564/2023 タイトル: 難治性腹水に選択的β₁-blockerが有効であったBudd-Chiari症候群の一例 著者: 小嶌, 秀之; 松村, 雅彦; 菊川, 政次; 高木, 正博; 森田, 倫史; 福井, 博; 辻井, 正 抄録: A 36-year-old female with Budd-Chiari syndrome who had refractory ascites and hepatic failure is reported. Sodium restriction, infusion of albumin, and administration of various diuretics were not effective. Because the effect of β-blocker on portal hypertension had been reported and portal hypertension was considered to be one of the main causes for ascites in this case, selective β₁-blocker metoprolol (80 mg/day) was added to diuretics. As a result, her ascites rapidly disappeared. Selective β₁-blocker has no adverse effect on hepatic blood flow, and therefore was considered to be relatively safe for patients with severe liver disturbance. Selective β₁- blocker seems to be promising in the treatment of refractory ascites, for which portal hypertension has a major pathogenetic role. Sun, 30 Dec 1990 15:00:00 GMT http://hdl.handle.net/10564/2023 1990-12-30T15:00:00Z http://hdl.handle.net/10564/2022 タイトル: CLINICOPATHOLOGICAL STUDY OF CEREBRAL SUBCORTICAL CAVERNOUS ANGIOMA AS EPILEPTOGENIC FOCUS 著者: Tsunoda, Shigeru; Sakaki, Toshisuke; Morimoto, Tetsuya; Nakase, Hiroyuki; Hashimoto, Hiroyuki; Goda, Kazuo; Kawai, Shozo; Ohnishi, Hideyuki; Hisanaga, Manabu 抄録: The authors conducted a comparative histological study of two groups of patients with cerebral subcortical cavernous angioma. One group was composed of 5 asymptomatic cases detected accidentally. The other group was composed of 4 patients presenting as epilepsy. The results obtained may be summarized as follows ; 1) Hemosiderin deposit and gliosis were seen in all cases examined ; 2) Granulomatous change was a histological finding associated with epileptogenesis ; 3) The histological changes, starting with proliferation of collagen fibers and leading to hyaline degeneration, calcification, and then hemangioma calcificans, seem to represent a course of spontaneous healing, when viewed from epileptogenesis. Sun, 30 Dec 1990 15:00:00 GMT http://hdl.handle.net/10564/2022 1990-12-30T15:00:00Z http://hdl.handle.net/10564/2021 タイトル: 旋毛虫感染の免疫学的研究 ： 感染経過より見た筋肉幼虫各抗原に対する宿主抗体産生について 著者: 水野, 直人 抄録: Fischer rats were experimentally infected with Trichinella spiralis and class-specific antibody response against the infection was followed up until 32 weeks after infection by means of indirect ELISA, immunoelectron microscopy (IEM), and western blotting. By indirect ELISA, the titer of specific IgG against crude antigen of T. spiralis muscle larvae increased from 2 weeks after infection, and kept high levels up to 32 weeks, but the titer of specific IgM was very low through the infection course. On the other hand, the titer of specific IgG against excretion and secretion antigen of muscle larvae began to increase from 4 weeks onward, and specific IgM was detectable from 3 weeks onward. These results indicate that different kinetics of antibody response (both IgG and IgM) are induced by different antigens, which was also confirmed by the following two methods. One method is immunoelectron microscopy using resin-embedded larvae as a substrate and infected sera as a staining antibody, which clearly revealed that there are two types of antigen : rapid responding antigens, and slow responding antigens. G class antibodies against the former including the cuticle inner layer, hypodermis, cord, hemolymph, intestinal gland cell granules, glycogen aggregates, discrete areas of genital primordial cell cytoplasm, and midgut occupying substance, were detectable from earlier phase of infection, while G class antibodies against the latter including the cuticle surface, stichocyte granules, and esophagus occupying substance, were detectable from relatively late phase of infection. M class antibodies against rapid responding antigens were undetectable or weak if any, but reactivity of M class antibody against slow responding antigens increased appreciably. The same tendency was observed by the other method, namely western blotting. The rapid responding antigens included ones from bands of pⅠ 4.4～4.7, 4.9～5.4 and 6.3～6.5 ; the slow responding antigens included ones from bands of pⅠ 4.0 and 5.4. The present contribution established that muscle larvae of T. spiralis contain two major types of antigens (rapid responding antigens and slow responding antigens) and the chronology of class-specific antibody response against each antigen is described, which will be indispensable for analysing any Trichinella-related immune response, especially for application to immunodiagnostic method of the disease. Sun, 30 Dec 1990 15:00:00 GMT http://hdl.handle.net/10564/2021 1990-12-30T15:00:00Z