http://hdl.handle.net/10564/1850 1992-12 Fri, 10 Apr 2026 15:23:14 GMT 2026-04-10T15:23:14Z http://hdl.handle.net/10564/1857 タイトル: 第113回奈良医学会 : 学会記事 Wed, 30 Dec 1992 15:00:00 GMT http://hdl.handle.net/10564/1857 1992-12-30T15:00:00Z http://hdl.handle.net/10564/1856 タイトル: IgA腎症を合併した先天性第Ⅶ因子欠乏症の1症例 著者: 山口, 充子; 土肥, 和紘; 椎木, 英夫; 竹中, 義正; 石川, 兵衞 抄録: A 32-year-old man associated with factor Ⅶ deficiency and IgA nephropathy is reported. According to his family history, the patient's parents were cousins in marriage and his younger brother was also affected by factor Ⅶ deficiency. Twenty-five years ago, moderate proteinuria (1-3 g/day) was first discoverd. A renal biopsy specimen showed mild to moderate mesangial proliferative glomerulonephritis with IgA deposits. Hemostatic tests demonstrated typical factor Ⅶ deficiency : marked prolongation of coagulation time, partial thromboplastin time and absence of factor Ⅶ. In his past clinical course he had had a transient cerebrovascular attack presenting with left hemiparesis 15 years ago. At last observation, his renal function remained normal although moderate proteinuria persisted. To the author's knowledge, this is the first reported case associated with these two diseases. Wed, 30 Dec 1992 15:00:00 GMT http://hdl.handle.net/10564/1856 1992-12-30T15:00:00Z http://hdl.handle.net/10564/1855 タイトル: 白血球除去フィルター(Sepacell R-500 A/Pall PL 50/100)使用による抗血小板抗体産生に及ぼす効果 著者: 下山, 丈人; 藤村, 吉博; 河本, 順雄; 西田, 幸世; 吉田, 英里; 水本, 保子; 八木, 秀男; 松本, 雅則; 山中, 貴世; 森井, 武志; 西川, 潔; 成田, 亘啓 抄録: To minimize various post-transfusion complications caused by white blood cell components, Sepacell R-500 A filters (Asahi Medical) for red blood cell products and PL 50/100 filters (Pall) for platelet products to remove white blood cells were clinically used in a total of 46 patients with leukemia and its allied disorders, and the results were compared with those of 19 patients with whom the filters were not used. Platelet allo-antibodies, assayed by mixed passive haemagglutination (MPHA) method, developed in 10 patients out of 19 (52.6%) without use of the filters and in 8 patients out of 22 (36.4%) with whom the filters were partially used. However, development of such antibodies was significantly lower when pre-filtered blood products were used throughout ; only two patients out of 24 (8.3%). Another common complication, a non-hemolytic febrile reaction, was also considerably reduced by using these filters. Therefore, we recommend that these filters should be used from the beginning of transfusion therapy, and that their use should never be interrupted throughout the treatment. Wed, 30 Dec 1992 15:00:00 GMT http://hdl.handle.net/10564/1855 1992-12-30T15:00:00Z http://hdl.handle.net/10564/1854 タイトル: 糖尿病性腎症における尿中レクチン結合性低分子糖蛋白分画 著者: 森本, 真弓; 金内, 雅夫; 中島, 靖夫; 西浦, 公章; 土肥, 和紘; 石川, 兵衞; 土肥, 祥子; 森山, 忠重 抄録: To evaluate the severity of diabetic renal involvement, we performed electrophoretic analysis of urinary glycoprotein for 16 patients with diabetic nephropathy using peroxidase-lectins. After being subjected to SDS-polyacrylamide gel electrophoresis, urinary glycoprotein was transferred to the nitrocellulose membrane, which then was stained with peroxidase labeled-lectin (Triticum vulgaris ; WGA), and was analyzed densitometrically. Electrophoretic analysis of urinary glycoprotein revealed the presence of lectin-reactive glycoproteins with the molecular weights of 22 kD, 32 kD, 38 kD and 48 kD respectively. Among these, the amount of the 22 kD-mol. wt. glycoprotein increased significantly as the renal histopathological changes developed, whereas that of 32 kD decreased. These results suggest that semiquantitative analysis of low molecular weight urinary glycoprotein stained with lectin is useful for the non-invasive evaluation of the severity of diabetic nephropathy. Wed, 30 Dec 1992 15:00:00 GMT http://hdl.handle.net/10564/1854 1992-12-30T15:00:00Z