http://hdl.handle.net/10564/1566 2004-10 Fri, 10 Apr 2026 15:41:16 GMT 2026-04-10T15:41:16Z http://hdl.handle.net/10564/251 タイトル: 食道表在癌放射線治療著効後に照射野内に発見され内視鏡的治療で根治しえた食道粘膜癌の3例 著者: 浅川, 勇雄; 玉本, 哲郎; 吉村, 均; 松尾, 祥弘; 伊藤, 高広; 中西, 攝子; 城根, 憲久; 鎌田, 喜代志 抄録: In general, salvage EMIR after radiotherapy (RT) is regarded as contra- indicated in esophageal cancer. We report here three cases of mucosal esophageal cancer found within the irradiated field of previous RT and treated successfu11y with EMR and local heating therapy. Case 1, a 73-year-old man, was diagnosed with operable squamous cell carcinomas (SCCs) of the esophagus (T1bN0M0: stage I). We performed radical radiotherapy (RT) of 70 Gy and the responses of these tumors were complete response (CR). Twenty-four months after RT, we found metachronous mucosal esophageal cancer within the irradiated field. Case 2, a 57-year-old man, was diagnosed with SCCs of the esophagus (T1aN0M0: stage 0). We tried to perform endoscopic mucosal resection (EMR) for the tumors, but could not resect them completely. Then, we performed additional RT of 60 Gy for the residual tumors. The tumor responses were CR. Twenty months after RT, we found recurrent mucosal esophageal cancer. Case 3, an 81-year-old man, was diagnosed with SCC of the esophagus (T1bN0M0: stage I). We performed radical RT of 60 Gy because of his advanced age, and the tumor response was CR. But 6 months after RT, we found recurrent mucosal esophageal cancer. For these mmors, we performed EMR and local heating therapy. In conclusion, these endoscopic treatments may be useful in patients with mucosal esophageal cancer within the irradiated field. Sat, 30 Oct 2004 15:00:00 GMT http://hdl.handle.net/10564/251 2004-10-30T15:00:00Z http://hdl.handle.net/10564/250 タイトル: SHIFT OF AXIAL POSITION FOR ROTATION AT THE INTERVERTEBRAL JOINT IN DOGS 著者: Tohno, Yoshiyuki; Tohno, Setsuko; Azuma, Cho; Moriwake, Yumi; Kumai, Tsukasa; Yamada, Gen 抄録: To elucidate whether the position of axis for rotation at the intervertebral joint is related with the spinal curvature, the authors investigated the spinal columns of beagles. The spinal column of beagle was composed of 7 cervical, 13 thoracic, 7 lumbar, 3 sacral, and 19 coccygeal vertebrae. It was observed that the position of axis for rotation at the intervertebral joint was shifted on the superior and inferior views of the 2nd thoracic vertebra and was next shifted on the superior and inferior views of the 10th thoracic vertebra. It was suggested that in the case of beagle and Wistar rat with 13 thoracic vertebrae, the upper shift of axial position for rotation at the intervertebral joint occurred on the superior and inferior views of the 2nd thoracic vertebra and the lower shift of axial position for rotation at the intervertebral joint occurred on the superior and inferior views of the 10th thoracic vertebra. Sat, 30 Oct 2004 15:00:00 GMT http://hdl.handle.net/10564/250 2004-10-30T15:00:00Z http://hdl.handle.net/10564/249 タイトル: 小児胆道拡張症に対するMRCPの有用性と問題点 著者: 鹿子木, 英毅; 金廣, 裕道; 岡山, 順司; 高, 済峯; 中島, 祥介; 北野, 悟; 廣橋, 伸治; 豊坂, 昭弘 抄録: Evaluation of biliary anatomy and arrangement of the pancreatobiliary maljunction is critically important in patients with choledochal cysts before surgical therapy. Although endoscopic retrograde cholangio-pancreatography (ERCP) has been a golden standard for preoperative evaluation of choledochal cysts, there are some difficulties in performing this method in pediatric patients due to its invasiveness. Recently, magnetic resonance cholangiopancreaticography (MRCP) was developed and has been established as a less invasive diagnostic modality for the pancreatobiliary duct system. We applied MRCP for ten pediatric patients with choledochal cysts. The bile duct system was successfully visualized in all cases. Irnages of pancreatobiliary maljunction were provided from MRCP in 5 of 9 patients who underwent MRCP before operation. In conclusion, MRCP is a less invasive and quite useful diagnostic modality for imaging of the pancreatobiliary duct system in pediatric patients with choledochal cysts. Sat, 30 Oct 2004 15:00:00 GMT http://hdl.handle.net/10564/249 2004-10-30T15:00:00Z http://hdl.handle.net/10564/248 タイトル: 銅キレート剤トリエンチンの抗血管新生作用と肝癌発育および肝発癌抑制効果の検討 著者: 吉井, 純一 抄録: Angiogenesis is now recognized to play a pivotal role in tumor development, and even in the process of carcinogenesis. Trientine dihydrochloride (trientine) is used in clinical practice as a copper (Cu)-chelating agent. In this study, we elucidate that the effect of trientine on tumor development and carcinogenesis is due to the suppression of angiogenesis in the murine hepatocellular carcinoma cell (HCC) xenograft model and in the rat hepatocarcinogenesis model, respectively. Trientine suppressed the tumor development associated with suppression of intra-tumoral angiogenesis. Trientine treatment also resulted in a marked increase of apoptosis in the tumor, although tumor cell proliferation itself was not altered. In vitro studies also showed that trientine is not cytotoxic for the tumor cells, but it significantly suppressed the endothelial cell proliferation. In a diethylnitrosamine (DEN)-induced rat hepatocarcinogenesis model, trientine treatment significantly suppressed glutathione S-transferase placental form (GST-P)-positive preneoplastic lesions. Trientine also markedly suppressed neovascularization in the liver to a similar level as that of development of preneoplastic lesions. On the contrary, the intrahepatic cell proliferation was not altered with or without trientine treatment. These results suggested that Cu plays a pivotal role in HCC tumor development and carcinogenesis via angiogenesis suppression. Since trientine is already used in clinical practice without any serious side effects, it may be an effective new strategy for future HCC therapy. Sat, 30 Oct 2004 15:00:00 GMT http://hdl.handle.net/10564/248 2004-10-30T15:00:00Z