http://hdl.handle.net/10564/1540 2000-10 Fri, 10 Apr 2026 15:38:30 GMT 2026-04-10T15:38:30Z http://hdl.handle.net/10564/629 タイトル: 思春期発症の精神分裂病の経過中に思春期妄想症様症状を呈した一例 著者: 徳山, 明広; 森川, 将行; 稲田, 直子; 武原, 弘典; 石田, 英和; 岸本, 年史; 飯田, 順三 抄録: We report a case of adolescent-onset schizophrenia which showed adoles- cent-paranoia-like symptoms in the course. Adolescent paranoia is a clinical entitity in which the individual has discomforting delusional conviction against someone close to him because of self-convinced physical abnormality and fear of emitting body odor, eye-to-eye confrontation, and so on. Adolescent paranoia has also been considered to be a severe type of anthropophobia and related to hypersensitivity in interpersonal relationships. The 21- year-old male schizophrenic patient demonstrated the psychiatric symptoms, which consist- ed of auditory hallucination, delusional mood, delusion of persecution and adolescent- paranoia-like symptoms. He had a hypersensitive and narcissistic personality ; therefore, his adolescent-paranoia-like symptoms might be linked to his hypersensitivity in interper- sonal relationships, which occurred in his mind when he faced the gap between his ego and his narcissistic ego ideal. Mon, 30 Oct 2000 15:00:00 GMT http://hdl.handle.net/10564/629 2000-10-30T15:00:00Z http://hdl.handle.net/10564/628 タイトル: 40隻寄生をみとめた胃アニサキス症の一例 著者: 吉川, 正英; 城井, 啓; 山田, 高嗣; 神田, 靖士; 石坂, 重昭; 上田, 重彦; 松村, 雅彦; 菊池, 英亮; 栗山, 茂樹; 福井, 博; 米田, 諭; 山根, 佳子; 岩澤, 秀; 西村, 公男 抄録: We report a case of gastric anisakiasis infected with forty worms. A 53- year-old male under chronic hemodialysis therapy was hospitalized because of nausea, vomiting and epigastralgia. These symptoms developed about two hours after the patient had eaten Saba-sushi. He also felt an itch on his back. An endoscopic examination, performed in the morning of the next day, revealed erosive gastritis accompanied by forty larval nematodes. We made a diagnosis of gastric anisakiasis. Twenty worms were removed from the stomach by a biopsy clipper. The remaining twenty worms were left in the stomach, because the patient was not able to tolerate to a prolonged endoscopic examination. However, clinical symptoms gradually disappeared in a few days, although some itches recurred on his face, abdomen and back. The endoscopic examination, performed on the fifth hospital day, revealed almost healed gastric mucosa and four living worms in the stomach. All of the four worms were removed endoscopically. Although gastric anisakiasis is the most common parasite disease of the gastrointestinal tracts, most cases of gastric anisakiasis were infected with one or two worms. The present case of gastric anisakisiasis infected with forty worms is relatively rare. Mon, 30 Oct 2000 15:00:00 GMT http://hdl.handle.net/10564/628 2000-10-30T15:00:00Z http://hdl.handle.net/10564/627 タイトル: EXPRESSION OF CD80/CD86-CD28 COSTIMULATORY MOLECULES BY PERIPHERAL BLOOD MONONUCLEAR CELLS AND SALIVARY GLANDS OF PATIENTS WITH SJÖGREN'S SYNDROME 著者: Umemura, Yasuyoshi 抄録: Objective. To investigate the expression of costimulatory molecules CD80, CD86, and CD28 on peripheral blood monouclear cells (PBMC) and in salivary gland (SG) biopsy tissues of patients with Sjögren's syndrome (SS). Methods. Monoclolal antibodies against CD80, CD86, and CD28 were used for flow cytometry and immunohistochemistry. PBMC CD80, CD86, and CD28 were studied in 21 patients with primary SS and 22 healthy controls, and biopsy tissues were studied in 12 patients with primary SS and 5 with secondary SS (3 with systemic lupus erythematosus and 2 with rheumatoid arthritis). Results. CD28 expression on CD4^+ and CD8^+ T cells was lower in SS patients than in normal controls. CD80 and CD86 were expressed on infiltrating mononuclear cells (MNC) in SG biopsy specimens ; the majority were adjacent to acini and ducts, with a few MNC in large lymphoid aggregates. Staining for CD80 and CD86 also revealed positive acinar and ductal endothelial cells in SG biopsy specimens. Conclusion. A costimulatory signal CD80 and CD86 may be required for the induction of lymphoepithelial lesions of SG, but not for progression of SS. CD80 and/or CD86 expressed on acinar and ductal endothelial cells is associated with activation of T cell in SG tissues of SS patients. Mon, 30 Oct 2000 15:00:00 GMT http://hdl.handle.net/10564/627 2000-10-30T15:00:00Z http://hdl.handle.net/10564/626 タイトル: アンジオテンシン変換酵素阻害剤の抗血管新生作用による肝癌発育抑制効果の検討 著者: 河田, 充弘 抄録: Since angiogenesis is essential for the growth of any solid tumor, emerging efforts are being made to develop anti-angiogenic therapy. To date, however, no anti- angiogenic agent has become widely available in clinic. Angiotensin-Ⅰ converting enzyme (ACE) inhibitors are commonly used as antihypertensive agents, and have tecently been suggested to decrease the risk of cancer. Here we show an ACE inhibitor, perindopril appears to be a potent inhibitor of tumor development and angiogenesis at clinical doses, whereas angiotensin-Ⅱ receptor antagonists do not exert such an inhibitory effect. The potent angiogenic factor, vascular endothelial growth factor (VEGF) is significantly suppressed in tumors by perindopril, and it also inhibits VEGF-induced tumor growth. In vitro studies showed that perindopril is not cytotoxic for either tumor cells or endothelial cells. Since perindopril is already in widespread use clinically, it may represent a potential new strategy for anticancer thefapy. Mon, 30 Oct 2000 15:00:00 GMT http://hdl.handle.net/10564/626 2000-10-30T15:00:00Z