DSpace コレクション: 1995-06

AUDITORY P300 EVENT-RELATED POTENTIALS AND MINI MENTAL STATE EXAMINATION PERFORMANCE IN DEMENTIA ; EFFECTS OF IDEBENONE AND VINPOCETINE

Thu, 29 Jun 1995 15:00:00 GMT

タイトル: AUDITORY P300 EVENT-RELATED POTENTIALS AND MINI MENTAL STATE EXAMINATION PERFORMANCE IN DEMENTIA ; EFFECTS OF IDEBENONE AND VINPOCETINE 著者: Kishimoto, Toshifumi; Hiraoka, Yukie; Oribe, Hiroaki; Inoue, Makoto; Ueda, Atsushi; Matsuyama, Mitsuharu; Inoue, Yuichiro; Itoh, Takashi; Yoshitomi, Katsunari; Miyagi, Tetsuro; Masuda, Nobuaki; Tatsuda, Hiroshi; Nakanishi, Yasuo; Negoro, Hideki; Ikawa, Genro 抄録: One group of twenty-one demented patients were administered Idebenone 90 mg/day for eight weeks, the other group of thirty-two demented patients were adminis- tered Idebenone 90 mg/day plus Vinpocetine 15 mg/day for eight weeks. Mini Mental State Examination (MMSE) was carried out and auditory event-related potentials (ERPs) were recorded pre-treatment, after four weeks treatment and after eight weeks treatmet. MMSE performance was significantly improved with treatment in both groups. Central P300 latency was shortened in the group which was treated with Idebenone and Vinpocetine, but not in the group which was treated with Idebenone alone. Based on the obtained results, we were convinced that administration of Idebenone and Vinpocetine was very useful in the treatment of vascular dementia.

DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY (DRPLA) AND MIDLATENCY AUDITORY EVOKED RESPONSES

Thu, 29 Jun 1995 15:00:00 GMT

タイトル: DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY (DRPLA) AND MIDLATENCY AUDITORY EVOKED RESPONSES 著者: Kishimoto, Toshifumi; Higashiura, Naoto; Hiraoka, Yukie; Sakiyama, Shinobu; Kirita, Ikuhiro; Noriyama, Yoshinobu; Itoh, Naoto; Ueda, Atsushi; Oribe, Hiroaki; Ikawa, Genro 抄録: The human 'P1' middle latency evoked potential is postulated to be generat- ed in the thalamus by a cholinergic component of the ascending reticular activating system. To test the midbrain function of dentatorubral-pallidoluysian atrophy (DRPLA), recording of middle latency response to click stimuli were carried out in a DRPLA family which was detected with the aid of molecular diagnosis. Comparisons between the DRPLA members and the normal members indicated normal Pa responses but P1 component is abnormal in DRPLA. This P1 abnormality suggests that the midbrain cholinergic cells in DRPLA may be dysfunctional.

担癌マウスにおける腫瘍の発育, 生存, 血中リンパ球サブセットに及ぼす脾摘の影響

Thu, 29 Jun 1995 15:00:00 GMT

タイトル: 担癌マウスにおける腫瘍の発育, 生存, 血中リンパ球サブセットに及ぼす脾摘の影響著者: 渡邉, 巌抄録: The spleen is the largest peripheral lymphoid tissue and plays an important role as one of the immune associated organs, but the effect of splenectomy in cancer therapy remains obscure. The tumor growth, host survival, and the change of T-lymphocyte subsets (Lyt2⁺, L3 T4⁺) in blood and spleen were studied using tumor bearing mice (Colon 26 bearing BALB/c mice) to investigate the effect of splenectomy, and the following results were obtained. 1. In cotrol group (CONT), the subcutaneous mass appeared macroscopically in the 8th day after tumor inoculation (Colon 26,2×10⁴), and started to death on the 30th day. Lyt2⁺ and L3 T4⁺ ratio of spleen elevated to the highest level on the 6th day and returned to the same level with tumor growth, on the other hand, Lyt2⁺ ratio of blood kept constant regardless of tumor growth, and L3 T4⁺ ratio dropped to the lowest level on the 9th day, and returned to the same level with tumor growth. 2. When splenectomy was done on the 5th day after tumor inoculation (SPN 5 ; early phase), Lyt2⁺ ratio of blood was significantly decreased (p<0.05) as compared with other groups, and subsequent enhancement of tumor growth and the shortening of survival period were observed (p<0.05). 3. On the 10th day after tumor inoculation (SPN 10 ; middle phase), Lyt2⁺ ratio of blood was significantly elevated (p<0.05) as compared with other groups, and subsequent inhibition of tumor growth and elongation of survival period were observed. 4. On the 20th day after tumor inoculation (SPN 20 ; late phase), blood T-cell subsets did not show great change, and subsequent enhancement of tumor growth and the shortening of survival period were observed. These results suggest that splenectomy of tumor bearing mice induces the change of blood T-cell subsets, and affects the tumor growth and host survival ; early splencectomy works tumor-enhancement, and middle splenectomy works tumor-inhibition ; also surgical damage as well as late splenectomy works tumor-inhibition.

好酸球における活性化抗原CD69の発現

Thu, 29 Jun 1995 15:00:00 GMT

タイトル: 好酸球における活性化抗原CD69の発現著者: 森井, 武志抄録: The activation antigen, CD69, has been shown to be expressed on activated lymphocytes. CD69 has also been shown to be associated with the signal transduction process. In this study, the author performed flowcytometric analysis of CD69 expression on eosinophils obtained from the bronchoalveolar lavage fluid (BALF), pleural effusion, or peripheral blood (PB) of various patients. Whatever the diseases were, lung eosinophils obtained from BALF or pleural effusion expressed significant levels of CD69, whereas most PB eosinophils did not express CD69. Further, CD69 expression was induced on PB eosinophils by the activation of interleukin-3 (IL-3), IL-5, granulocyte macrophage colony stimulating factor (GM-CSF), interferon-a (IFN-α) and phorbol myristate acetate (PMA), but platelet activating factor (PAF) did not induce CD69 expression. CD69 expression induced by IL-3 or GM-CSF was in a dose and time dependent manner. The expression could be induced significantly at low concentration of 10 pg/ml and was detected after stimulation for two hours. These findings suggest that CD69 expressions are restricted to local eosinophils, and that local eosinophils may stand at a different activating state from PB eosinophils.