http://hdl.handle.net/10564/3564 2018-12 2026-04-09T11:08:48Z http://hdl.handle.net/10564/3567 タイトル: 第138回奈良医学会 : 学会記事 2018-12-30T15:00:00Z http://hdl.handle.net/10564/3566 タイトル: Protumoral Effect of Angiotensin System. 著者: Fujiwara-Tani, Rina; Matsushima-Otsuka, Sayako; Nishiguchi, Yukiko; Mori, Shiori; Kuniyasu, Hiroki 抄録: Colorectal cancer (CRC) cells possess an angiotensin activation mechanism provided by the expression of renin and chymase. Renin expression is induced by a hyperglycemic condition. Since angiotensinogen is produced in the liver, CRC cells with angiotensin-activating machinery possess an advantage to metastasize to the liver. In human CRC cases, the diabetes-complicated patients show higher concentrations of renin and angiotensin-Ⅱ in the primary tumors, and a more progressed disease stage, especially, liver metastasis in association with HbA1c levels than those in the patients without diabetes. Concurrent treatment with anti-angiotensin and hypoglycemic agents shows a synergic effect of decreasing liver metastasis and improving the survival of diabetic mice in the CRC liver metastasis model. MAS1-angiotensin1-7 is a negative regulator of the AGTR1-angiotensin Ⅱ axis in breast cancer. Notably, MAS1 is overexpressed in triple negative breast cancer, which might be a novel molecular target for the treatment-refractory entity of breast cancer. Nuclear AGTR2 and intracellular angiotensin-Ⅱ play a role in anti-apoptotic and anti-oxidative stress properties. These functions of nuclear AGTR2 might mitigate "anti-tumoral side effects" of AGTR1 and angiotensin-Ⅱ system, which enhance mainly tumor progression. The effect of anti-angiotensin treatment such as ARB and blood sugar control as ab aseline management of many cancer patients needs to be examined in a clinical situation for prevention of RAS-induced tumor progression. 2018-12-30T15:00:00Z http://hdl.handle.net/10564/3565 タイトル: 表紙、目次、総目次、投稿規程詳細、奥付(Vol.69 No.4,5,6) 2018-12-30T15:00:00Z http://hdl.handle.net/10564/3560 タイトル: A Sensitive and Time-Saving Method for the Diagnosis of Drowning by Multiplex PCR. 著者: Nakanishi, Mari; Nakayama, Akifumi; Kasuda, Shogo; Kudo, Risa; Yuui, Katsuya; Ishitani, Akiko; Hatake, Katsuhiko 抄録: For diagnosing death due to drowning, the method of acid digestion of diatoms is widely used to detect plankton in the organs of the corpse. However, the method is limited by its　being complex, hazardous, time-consuming, and insufficiently sensitive. We therefore, developed a novel simple method to diagnose death due to drowning, and determined the location of drowning by detecting genes of representative bacteria in the environment. To procure all the information in one step, the multiplex PCR method was designed. For the diagnosis of drowning, the genes of upper respiratory indigenous bacteria, Streptococcus salivarius and Streptococcus sanguinis were used as indicators. For detection of the location of drowning, Aeromonas hydrophila and Microcystis aeruginosa were used as indicators of freshwater, and Vibrio harveyi as an indicator of seawater. A set of primers was designed for multiplex PCR. to amplify all the bacterial genes simultaneously. Using this method, 47 cases of drowning were examined, and the causes and locations of death were diagnosed. 内容記述: 博士（医学）・乙第1428号・平成31年3月15日 2018-12-30T15:00:00Z