http://hdl.handle.net/10564/3147 2015-04 2026-04-10T15:30:55Z http://hdl.handle.net/10564/3153 タイトル: 第134回奈良医学会 : 学会記事 2015-04-29T15:00:00Z http://hdl.handle.net/10564/3152 タイトル: 3次元Multi-detectorCT画像により早期診断し，大腸内視鏡下に摘出し得た爪楊枝による超高齢者大腸穿通の1例 著者: 杉山, 浩平; 松山, 友美; 白井, 謙一; 簗瀬, 公嗣; 浪崎, 正; 山崎, 正晴; 吉治, 仁志; 福井, 博 抄録: We present herein a case of sigmoid penetration, caused by accidental ingestion of a toothpick and resolved by endoscopic removal. An 85-year-old woman with moderate dementia was referred to our hospital by the primary care doctor for a further examination of minor localized left lower quadrant rebound tenderness. Multi-detector CT (MDCT) revealed sigmoid colon penetration by a linear structure and adjacent opaque adipose tissue. She was admitted as an emergency case to our hospital with localized peritonitis. A 3D reconstruction image confirmed that a 6 cm-long toothpick had pierced the sigmoid colon. However, the abdominal CT scan showed sigmoid colon penetration with no evidence of abscess formation or free air. Toothpick ingestion-related penetration was successfully managed with an endoscopic retrieval procedure followed by broad-spectrum antibiotic coverage. She was eventually discharged in fair condition. Here, we report this case of an 85-year-old female patient with accidental toothpick ingestion who was diagnosed with sigmoid colon penetration by MDCT with 3D reconstruction, and underwent successful endoscopic removal. 2015-04-29T15:00:00Z http://hdl.handle.net/10564/3151 タイトル: 奈良県立医科大学口腔外科・口腔ケア外来における周術期口腔機能管理症例の臨床的検討 著者: 東浦, 正也; 青木, 久美子; 伊地知, 由賀; 木下, 小百合; 吉田, 美和; 正木, 綾香; 堀田, 聡; 三宅, 達郎; 桐田, 忠昭 抄録: A total of 302 patients who enrolled for perioperative oral functional management for a year from April 2013 to March 2014 were analyzed in the Department of Oral and Maxillofacial Surgery, Nara Medical University Hospital. It was intended for patients whose it was possible to calculate the "perioperative oral functional management fee" could be calculated. One hundred and eighty four cases (60.9%) were male and one hundred and eighteen cases (39.1%) were female, and the median age was 67.0 ± 11.1. Most patients were referred from the Department of Cardiovascular Surgery (77 cases, 25.5%). The primary diseases that the patients suffered from comprised 213 cases (68.5%) of malignant tumor, 85 cases (27.3%) of heart disease, and 4 cases (1.3%) of kidney disease. The treatment regimen for the primary diseases comprised 152 cases (50.3%) of radiation therapy or chemotherapy, 119 cases (39.4%) of operations, and 31 cases (10.3%) of hematopoietic stem cell transplantation. The cases that we received included both patients already undergoing the treatment of the primary disease, as well as those whose treatment regimen had not yet started. Amongst the cases without any oral symptoms, 136 cases did not understand the need for oral functional management. Two hundred and forty five cases (81.1%) did not have a family dental clinic. Periodontal treatment was the most common form of oral functional management, followed by tooth extraction, repair and denture adjustment. The introduction rate from specific clinical departments is high. In addition, many patients receive our treatment course without understanding perioperative oral functional management. It is necessary to inform the patient and the physician about the efficacy of perioperative oral functional management. 2015-04-29T15:00:00Z http://hdl.handle.net/10564/3150 タイトル: エライジン酸の5-fluorouracil抗腫瘍効果に与える影響 著者: 北吉, 美沙穂; 田邊, 絵里子; 羅, 奕; 國安, 弘基 抄録: We studied the effects of elaidic acid (EA) has on the anti-tumor effect of 5-fluorouracil (FU). Examining the 5-FU sensitivity in mouse lung cancer cell line LL2, and mouse colorectal cancer cell lines CT26 and CMT93, CMT93 showed low sensitivity. The increased growth inhibitory effects in CT26, CMT93, and LL2 cells were 1.0-, 1.2-, and 1.1-times, respectively, on concurrent treatment with EA at an apoptosis-inducing concentration and 5-FU at a concentration of IC50. On examining aldehyde dehydrogenase (ALDH) activity changes in the cancer stem cells in this case, it was found to have been increased 3.8-fold by simultaneous treatment with 5-FU and EA in CT26 and LL2 cells, but 1.5-fold in CMT93 cells. In addition, considering the expression of nucleostemin as a stem cell marker, in simultaneous treatment with 5-FU and EA, and treatment with EA alone, the expression was increased in CT26 and LL2 cells, whereas the expression level did not change in CMT93 cells. The foregoing suggests that, rather than altering the 5-FU sensitivity of cancer cells, EA might promote the survival of cancer stem cells. The results suggest that the content of the diet during chemotherapy is a relevant issue. 2015-04-29T15:00:00Z