http://hdl.handle.net/10564/2982 1995-12 2026-04-10T15:40:39Z http://hdl.handle.net/10564/3012 タイトル: 第116回奈良医学会 : 学会記事 1995-12-30T15:00:00Z http://hdl.handle.net/10564/3011 タイトル: 超音波骨密度測定装置を用いた小児骨密度の検討 著者: 鈴木, 博; 西野, さやか; 西野, 正人 抄録: We analysed thirty healthy children (15 boys and 15 girls) and four patients under steroid therapy on bone mineral density (BMD), using a newly developed ultrasound bone densitometer. BMD was estimated with the value of stiffness of bone, which was calculated with SOS and BUA. The stiffness in boys increased from 75 to 96 in parallel with aging, as a regression line of Y=67.58±2.27 X. And those in girls showed a regression line of Y=68.38+1.40 X, ranging from 67 to 88. These results were correlative to those using DEXA. The stiffness in four patients under steroid therapy were lower than in healty children. Therefore, we supposed that the ultrasound bone densitometer would be useful for analysis of BMD in children. 1995-12-30T15:00:00Z http://hdl.handle.net/10564/3010 タイトル: 骨形成因子添加アテロコラーゲン溶液反復注入法による骨造成術に関する実験的研究 著者: 稲田, 育久 抄録: Bone morphogenetic protein (BMP) induces differentiation of mesenchymal-type cells into cartilage and bone in a number of species. Therefore, BMP has been investigated as an osteoinductive factor for preparation of a bone substitute. This preliminary report presents bone augmentation using repeated injection of atelocollagen (AC) solution with BMP in mice and rats. The crude BMP and bone type Ⅰ atelocollagen were prepared from fresh bovine bones. Intramuscular injection of the AC solution with crude BMP resulted in reproducible bone induction after 2 weeks. BMP activity depended on the concentration of the AC solution as a carrier, and the 0.75% AC solution with BMP induced the highest BMP activity. Repeated injection of the AC solution with BMP did not incite a significant decrease of BMP activity which suggested an immunological response inhibiting osteoinduction. The 3-consecutive-day subperiosteal injection over the rat cranium elicited significantly higher and wider deposits of bone formation than the 3-consecutive-week one after 8 weeks. Moreover, in the 3-consecutive-day injection, each injected implant unified as a mass. On the other hand, in the 3-consecutive-week injection, each induced bone deposit was individually encapsulated by fibrous connective tissues without unification. The repeated injection method of the AC solution with BMP resulted in extensive bone induction easily and reproducibly, in the consecutive-day injection. The results obtained suggest a possibility of c1inical applications of the repeated injection method of the AC solution with BMP not only for bone augmentation but also for all osseous reconstructions, considering the interval，f requency, and location of injection. 1995-12-30T15:00:00Z http://hdl.handle.net/10564/3009 タイトル: 温阻血およびサイクロスポリンAによるラット障害腎に対する心房性ナトリウム利尿ペプチド投与による影響 著者: 坂, 宗久 抄録: The nephrotoxicity of Cyclosporine A (CYA) is a serious problem, and constitutes the major obstacle limiting the use of CYA as an immunosuppressive agent for renal transplantation. On the other hand, the newly described atrial natriuretic peptide (ANP) hormonal system in both humans and animals appears to play an important role in sodium and water excretion. In study 1, the effect of recombinant-ANP (r-ANP) on warm ischemic (WI) damaged kidney was examined in six experimental groups. In study 2, the effects of r-ANP on kidneys damaged by WI followd by CYA administration, which is a similar condition in renal transplantation, were examined in four experimental groups. Consequently, the efficiency of r-ANP on renal function which was damaged by CYA and WI was shown to be verifiable. 1995-12-30T15:00:00Z