http://hdl.handle.net/10564/2298 2012-04 2026-04-09T03:48:08Z http://hdl.handle.net/10564/2305 タイトル: バイオベンチャー：科学とビジネスの最前線 ： オーダーメイドの解析と医療 著者: 新井, 賢一; 坪井, 昭夫 2012-04-29T15:00:00Z http://hdl.handle.net/10564/2304 タイトル: 腸閉塞をきたした小腸アニサキス症の1例 著者: 藤岡, 伸啓; 向川, 智英; 國重, 智裕; 西和田, 敏; 高, 済峯; 石川, 博文; 渡辺, 明彦 抄録: A 34-year-old man complaining of abdominal pain was admitted to our hospital with a diagnosis of ileus. He was suspected of having strangulated ileus and an emergency operation was performed. At laparotomy, we found an inflammatory tumor with redness and pus about 130 cm from Bauhin's valve on the oral side and did a partial resection of the ileum. Anisakiasis was found in the edematous mucosa of the resected specimen. We checked that he had eaten raw mackerel on the previous day. Anisakiasis of the small intestine is a relatively rare disease and often presents difficulty in preoperative diagnosis. We should consider the operative indication for Anisakiasis of the small intestine with ileus symptoms, because the disease condition will worsen to perforation and necrosis of the intestine. 2012-04-29T15:00:00Z http://hdl.handle.net/10564/2303 タイトル: アンジオテンシンⅡ刺激による血管平滑筋細胞の遊走に対するSrc阻害とMAPキナーゼ阻害効果の比較 著者: 趙, 晶; 京谷, 陽司; 伊藤, 都裕; 長山, 功佑; 小澤, 健太郎; 吉栖, 正典 抄録: Angiotensin Ⅱ (AⅡ) plays an important role in various cardiovascular diseases associated with vascular smooth muscle cell (VSMC) growth and migration. In our previous study, we investigated the effect of olmesartan, an angiotensin Ⅱ receptor　blocker, on AⅡ-induced Src tyrosine kinase, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) activation and rat aortic smooth muscle cell (RASMC) migration. We found that olmesartan inhibited AⅡ-induced ERK1/2 and JNK activation at lower concentrations. On the other hand, PP2, a Src tyrosine kinase inhibitor, also inhibited AⅡ-induced ERK1/2 and JNK activation, but its effect on ERK1/2 was less pronounced than that of olmesartan. However, both olmesartan and PP2 potently inhibited AⅡ-induced RASMC migration. In the present study, we investigated the involvement of Src on AⅡ-induced migration of RASMC using Src siRNA for gene silencing. Src siRNA was successfully introduced into RASMC using transfection procedures. We found that the inhibitory effect of Src siRNA on AⅡ-induced JNK activation was more potent than on ERK1/2 activation in RASMC. In addition, Src siRNA effectively inhibited AⅡ-induced RASMC migration to an extent similar to PP2. From these findings, it was inferred that direct inhibition of Src may be an effective option for VSMC growth and migration. Pharmacological or genetic inhibition of Src may be a strategy that can be used in addition to renin-angiotensin blockade for cardiovascular diseases involving AⅡ, such as hypertension and atherosclerosis. 2012-04-29T15:00:00Z http://hdl.handle.net/10564/2302 タイトル: 転移性脳腫瘍に対するLQモデルに基づく分割照射方法の効果比較 著者: 吉峰, 正; 池口, 俊孝; 石見, 浩; 福神, 敏; 上野山, 文男; 杉本, 正; 中瀬, 裕之; 玉本, 哲郎; 長谷川, 正俊 抄録: The Biologically Effective Dose (BED) based on the linear quadratic (LQ) model is often used for evaluating the effect of fraction size and total dose in fractionated radiotherapy ; however, it has recently been suggested that the BED is not always available for stereotactic irradiation (STI). In the present study, we analyzed the relationship between the different fractionation schedules and the efficacy of STI for metastatic brain tumors using the LQ model. The BED for each prescribed dose was calculated in stereotactic radiosurgery and stereotactic radiation therapy, and the tumor volume was evaluated using MRI images acquired during the follow-up after the irradiation. The cumulative probabilities of partial response rates (PRR) and disease control rates (DCR) were estimated as a function of the day after the initial treatment using the Kaplan-Meier method. Comparisons among the groups were accomplished using a log-rank test. SRS showed a significantly better PRR and DCR compared with SRT using a fraction size of 4Gy or less (p=0.0193 and p=0.0193, respectively). A single high dose radiation therapy has been suggested to be more effective than that predicted by the LQ model. 2012-04-29T15:00:00Z