http://hdl.handle.net/10564/2047 1990-08 2026-04-10T15:40:41Z http://hdl.handle.net/10564/2057 タイトル: 奈良県立医科大学附属病院口腔外科開設後5年間における外来患者の臨床統計的観察 著者: 堀内, 克啓; 服部, 明伸; 吉川, 智也; 中橋, 一裕; 土田, 雅久; 西岡, 博人; 露木, 基勝; 浅香, 信; 竹内, 尚則; 望月, 光治; 吉田, 育弘; 権, 利文; 桐田, 忠昭; 植村, 和嘉; 匠原, 悦雄; 河野, 孝行; 杉村, 正仁 抄録: The authors performed clinico-statistical observation on 10,013 out-patients who presented during the five years following the inception of Department of Oral and Maxillofacial Surgery, Nara Medical University Hospital, on 19th October 1976. The results are as follows : 1. The yearly average number of out-patients was 2,003, which was the largest of any Departmant of Dentistry and/or Oral and Maxillofacial Surgery Medical University Hospital. 2. 7,448 patients (74.4%) had diseases associated with oral and maxillofacial surgery, who were divided into the following 14 groups : inflammations (21.8%), traumas (19.4%), diseases of temporomandibular joint (12.1%), diseases of oral mucosa (8.7%), impacted teeth (7.1%), cysts (6.9%), tumors and tumor-like diseases (5.6%), anomalies (3.7%), diseases of salivary gland (2.3%), iatrogenic diseases (1.9%), diseases of nervous system (1.3%), blood diseases (0.5%), jaw deformities (0.2%), and others (7.8%). 3. 7,273 patients (72.6%) were referred by dentists (30.7%), medical doctors (35.9%) and others (6.0%). Patients with diseases of TMJ were referred by orthopedists (25.1%) more than dentists (22.1%), which suggests that this disease has not been generally recognized yet. 4. In 1,812 patients with general dental diseases, 832 patients (45.9%) had systemic diseases. 1990-08-30T15:00:00Z http://hdl.handle.net/10564/2055 タイトル: 奈良医大精神科外来における児童および思春期の患者の現況 著者: 岩坂, 英巳; 飯田, 順三; 平尾, 文雄; 松村, 一矢; 井川, 玄朗 抄録: Statistical research was conducted on the　out-patients who were under 18 years of age at their first visit to the psychiatric clinic at Nara Medical University Hospital from April 1982 to March 1983 and from April 1987 to March 1988. We adapted DSM-Ⅲ-R criteria to all patients and compared with classical diagnosis. The results are as follows. 1. 104 out-patients (55 male, 49 female) were seen from April 1982 to March 1983, and 121 out-patients (59 male, 62 female) were seen from April 1987 to March 1988. 2. About 20% of the patients visited the Departement of Psychiatry through the referral from the Departments of Pediatics and Internal Medicine in Nara Medical University. But there were few refferals from schools or children's consulting centers 3. The number of cases of Neurosis occupied about 50% of total cases. This is common to any other hospitals. 4. There is no category of School Refusal and Neurosis in DSM-Ⅲ-R, and so we tentatively categorized the patients with school refusal and neurosis accoding to DSM-Ⅲ-R. 5. School Refusal has incresed, especially among pupils in the higher grades of elementary schools and female junior high school students. 1990-08-30T15:00:00Z http://hdl.handle.net/10564/2054 タイトル: ニバレノール(マイコトキシン)の代謝と毒性機構に関する研究 ： 第二報．ラットにおけるニバレノールの吸収，代謝，排泄および毒性について 著者: 陰地, 義樹 抄録: Absorption, distribution, and excretion of nivalenol and its major metabolite, deepoxynivalenol, were invesitigated in male rats after a single intraperitoneal (1 mg/Kg) or oral (5 mg/Kg) administration. After intraperitoneal administration, nivalenol and deepoxynivalenol excreted by the rats in urine were 48.3% and 3.8% of the total dose given respectively, and those excreted in feces were 10.0% and 25.5% of the dose, respectivly, within 72 hr. On the contrary, in oral administration, nivalenol and deepoxynivalenol excreted in urine were 9.9% and 5.6% of the dose, respectively, and those excreted in feces were 5.4% and 18.7% of the dose, respectively, in 72 hr. Deepoxynivalenol was excreted in feces to a higher extent than in urine and later than nivalenol. The levels of nivalenol detected in serum, liver and kidney were much lower than in urine or feces even 1 hr after oral dosing and were rapidly lowered. Deepoxynivalenol was not detected in serum, liver, or kidney at any time within 24 hr. The major metabolic pathways of nivalenol in rats are considered to be the deepoxidation at 12, 13-epoxide ring in the gastrointestine. The effect of feeding diets containing 0, 10, and 50 μg/g of nivalenol for 8 weeks on the growth rate, hematology, and histopathology were also examined. In 50 μg/g nivalenol dosing group, body-weight gain was significantly reduced and weak erythrocytopenia was observed. Histopathologically, mucosal necrosis and the disruption of gut epithelium, and an increase of erythroid series in bone marrow was observed. However, in 10 μg/g nivalenol dosing group, no significant change was observed in comparison with the control group. 1990-08-30T15:00:00Z http://hdl.handle.net/10564/2053 タイトル: ニバレノール(マイコトキシン)の代謝と毒性機構に関する研究 ： 第一報．ニバレノールの単離精製と新代謝物 ； 脱エポキシニバレノールの同定 著者: 陰地, 義樹 抄録: Large amounts of two mycotoxins, nivalenol and fusarenon-X were produced from Fusarium graminearum F-1465 cultured on pressed barley. The centrifugal partition chromatography (CPC) using two-phase solvent systems n-butanol-water and chloroform-methanol-water could be applied to a preparative purification of nivalenol and fusarenon-X. Starting from the Fusarium grown on 1 kg of pressed barley substrate, 0.34 g of nivalenol and 0.78 g of fusarenon-X were obtained by recrystallization of CPC fraction from hot methanol. Fusarenon-X was converted to nivalenol by alkaline hydrolysis giving to 0.55 g of crystalline nivalenol. A new metabolite of nivalenol was detected in the feces of rats when nivalenol was administered orally. The new metaboite was identified as 3, 4, 7, 15-tetrahydroxytrichothec-9, 12-dien-8-one, or deepoxynivalenol, on the basis of mass spectrometry and ¹H and ¹³C nuclear magnetic resonance spectroscopy. In repeated oral administration, the deepoxy metabolite was detected in feces at 80% and in urine at 1% of total dose, and the parent compound was detected in feces at 7% and in urine at 1%, respectively. 1990-08-30T15:00:00Z