http://hdl.handle.net/10564/1863 2011-10 2026-04-10T15:44:02Z http://hdl.handle.net/10564/1878 タイトル: 第131回奈良医学会 : 学会記事 2011-10-30T15:00:00Z http://hdl.handle.net/10564/1877 タイトル: AN AUTOPSY CASE OF PORTOPULMONARY HYPERTENSION ASSOCIATED WITH ALCOHOLIC LIVER CIRRHOSIS 著者: Maruyama, Hiroshi; Toyoda-Hirana, Yuki; Nakamura, Takahito; Enomoto, Yasunori; Hamada, Kaoru; Kimura, Hiroshi 抄録: We report an autopsy case of pulmonary pexogenic arteriopathy associated with portal hypertension due to alcoholic liver cirrhosis, termed portopulmonary hypertension (PPHT). A 49-year-old man who has had alcoholic liver cirrhosis for 10 years complained of severe dyspnea (Fletcher-Hugh-Jones V). Chest CT revealed marked enlargement of bilateral hilar pulmonary arteries and cardiomegaly associated with right ventricular hypertrophy. The patient died from hepatic. encephalopathy and respiratory failure. Autopsy c1early revealed the wall thickness of pulmonary small vessels diffusely in peripheral fields on cut surfaces and marked dilatation of the main pulmonary artery, together with liver cirrhosis. Microscopically, the pulmonary small arteries demonstrated grade 5 pulmonary plexogenic arteriopathy inc1uding plexiform lesions and a micronodule resembling an arachnoid granulation or meningioma throughout the lungs. This case suggested that a typical plexogenic arteriopathy morphologically and definitely contributed to confirm PPHT, although the patient was c1inically suspected of hepatopulmonary syndrome (HPS). 2011-10-30T15:00:00Z http://hdl.handle.net/10564/1876 タイトル: MOLECULAR DETECTION OF MECT1-MAML2 FUSION GENE IN MUCOEPIDERMOID CARCINOMA WITH ORDINARY AND VARIANT HISTOLOGY: A STUDY USING ARCHIVAL PARAFFIN EMBEDDED TISSUE 著者: Kasai, Takahiko; Takeda, Maiko; Enomoto, Yasunori; Takano, Masato; Morita, kouhei; Nonomura, Akitaka 抄録: Mucoepidermoid carcinoma (MEC) has been characterized by t (11; 19)(q21; p13). This chromosomal translocation has been recently shown to generate a MECT1- MAML2 fusion gene. MEC can pose diagnostic challenges when they are of high-grade, of variant histologic appearance and occurring in an unusual site. The aim of this study was to evaluate the frequency of the MECT1-MAML2 fusion gene among primary salivary gland MECs and extrasalivary gland MECs, together with some histological variants and its role as a possible diagnostic adjunct, comparing the salivary gland tumors including Warthin's tumor(WT)，pleomorphic adenoma(PA)，and adenoid cystic carcinoma(ACC). Using a reverse transcription-polymerase chain (RT-PCR)-based approach, we assayed for the MECT1-MAML2 transcript in 39 cases for which paraffin- embedded tumor tissue with adequate RNA was available. These included 19 MECs，10 WTs， five PAs， and five ACCs. The MECT1-MAML2 fusion gene transcript was detected in 16 (84.2%) of 19 MECs. These positive cases included two cases of MEC with WT-like areas，a sclerosing MEC and a clear cell MEC. Three negative cases were high- grade MECs. Two of them were not easy to distinguish from squamous cell carcinoma. The MECT1-MAML2 fusion gene was negative in all cases of WT，PA and ACC. The potential usefulness of MECT1-MAML2 fusion gene expression as a molecular marker in the diagnosis of MEC is supported. 2011-10-30T15:00:00Z http://hdl.handle.net/10564/1875 タイトル: PLASMA CELL INFILTRATION AND MUCOID DEGENERATION IN THE MEDIA OF ASCENDING AORTA IN PATIENT WITH CORONARY ARTERY DISEASE 著者: Nagareda, Tomofumi; Hirata, Nobuaki; Kosakai, Yoshio; Ohsawa, Masahiko 抄録: Aims Atherosclerosis results in inflammatory changes in the aortic intima， but little is known regarding medial changes. Atherosclerosis of the ascending aorta coexists with coronary artery disease. The aim of this study was to investigate the atherosclerotic changes in 44 biopsy specimens of media of the ascending aorta associated with coronary artery disease. Plasma cells do not appear in non-inflammatory tissue. Methods We compared plasma cells，and matrix metalloproteinase (MMP)-2-，-9- and -12-positive cells immunohistochemically，and we also compared mucoid degeneration and fibrosis determined by staining using a point-counting method，for groups with a variable number of coronary stenotic (≧75%)lesions. Results In patients with one to three coronary stenotic lesions，plasma cells and mucoid degeneration were low in the aortic media. With four to five lesions，bo th plasma cells and mucoid degeneration increased significantly compared with those in the group with one to three lesions，and MMP-12-positive cells significantly decreased. In patients with six to nine lesions，the number of plasma cells was significantly lower than in patients with four or five lesions，whereas mucoid degeneration significantly increased. There was no change in fibrosis. Conclusions These findings may help us to better understand and treat atherosclerosis. 2011-10-30T15:00:00Z