http://hdl.handle.net/10564/1752 1993-12 2026-04-10T15:44:00Z http://hdl.handle.net/10564/1765 タイトル: 第114回奈良医学会 : 学会記事 1993-12-30T15:00:00Z http://hdl.handle.net/10564/1764 タイトル: Marfan症候群の一剖検例 著者: 平野, 佳成; 河原, 信吾; 石谷, 昭子; 伊藤, 信彰; 森村, 佳史; 東, 裕子; 廣田, 忠臣 抄録: A 28-year-old man who had been in apparently good health and had no diagnosed disease was found dead at work. Autopsy was carried out and showed that he was tall (183 cm in height) and lean with arachnodactyly, suspected to suffer from Marfan's syndrome, and revealed dissection involving ascending arch and descending portions of the aorta with rupture into the pericardiac sac. Microscopic examination of the wall of the aortic aneurysm disclosed fragmentation and focal loss of elastic fibers and existence of cystic medial necrosis in the media. Investigation of his family suggested that the disease has been dominantly inherited in his family. From these observations, the cause of death was supposed to be dissecting aneurysm with rupture into the pericardiac sac because of congenital Marfan's syndrome. Immunohistochemical localization of type Ⅰ, Ⅲ, Ⅳ collagen in the aorta demonstrated no significant difference in distribution between normal and diseased tissues of the present case. 1993-12-30T15:00:00Z http://hdl.handle.net/10564/1763 タイトル: 放射線照射による食品よりの旋毛虫感染予防に関する研究 著者: 島津, 公隆 抄録: A systemic study was performed to elucidate the effects of Co60 irradiation on maturation or fecundity of Trichinella spiralis by assessing from parasitological, morphological and immunological points of view. Pieces of muscle tissue of mice infected with T. spiralis were irradiated with Co60 at doses of 50, 75, 100, 150 and 200Gy. These irradiated tissues (Experimental group) and non-irradiated tissues (Control group) were fed to healthy mice. Half of the mice were sacrificed 6 days after the ingestion. The number of adult worms were counted and subjected to statistical analysis, which disclosed a good correlation between the dose of Co60 irradiation and worm damage ; the higher the dose the more damage parasites had, and no adults were recovered if the tissue had been irradiated with more than 150Gy prior to infection. The same tendecy was true for the histopathology of the intestines of host mice ; the higher the dose the less tissue damage. Circulating antigens of T. spiralis and antibodies against T. spiralis were detected in every serum examined by means of ELISA. The remaining mice were sacrificed 30 days after the ingestion. The numbers of muscle larvae were counted and subjected to statistical analysis, which disclosed a good correlation between the dose of Co60 irradiation and worm damage, and no larvae were recovered if the tissue had been irradiated with more than 75Gy. Higher concentrations of circulating antigens of T. spiralis and antibodies against T. spiralis were detected in the serum samples taken with muscle larvae. Thus this study established that Co60 irradiation of more than 150Gy caused complete damage on maturation, and that irradiation of more than 75Gy caused complete damage on the fecundity of T. spiralis. 1993-12-30T15:00:00Z http://hdl.handle.net/10564/1761 タイトル: 試作人工硝子体ポリビニールアルコールハイドロゲルに対する猿眼の病理組織学的評価 著者: 原, 徳子 抄録: The purpose of the present experiment is to study by clinical and histological methods the effects of artificial vitreous body made from polyvinyl alcohol hydrogel (PVA) in rhesus monkeys. Fifteen rhesus monkeys were used in the present experiment. Zero point three ml of PVA was injected into the right eye after 0.5 ml of the vitreous body was removed. As a control, 0.3 ml of physiological saline was injected into the left eye, after 0.5 ml of the vitreous body was removed. Clinical laboratory observations were done at 3 days, 1, 2, 4, 8, 12 and 16 weeks after PVA or physiological saline were injected. All eyes were removed at experiment week 16 and were used for histopathological studies. Adequate data could not be obtained in clinical observation, because of difficulty in controlling the intraocular pressure and secondary uveitis, the measurement of which required systemic anesthesia. In histological studies, granulation in outer sclera, mild infiltration of neutrophils, plasma cells and lymphocytes in the iris, granulation on the surface of the sclera, destruction of inner nuclear layer, decrease in the number of outer nuclear cells or fibrin with lymphocytes on the surface of vitreous body were seen in 8 of 12 experimental eyes. Further observations should be done on the adequacy of PVA for vitreous substitute before clinical use. 1993-12-30T15:00:00Z