http://hdl.handle.net/10564/1554 2008-04 2026-04-09T03:42:05Z http://hdl.handle.net/10564/332 タイトル: 口腔衛生習慣と生活機能との関連 : 奈良県御杖村全数調査 著者: 岡本, 希; 森田, 徳子; 佐伯, 圭吾; 車谷, 典男 抄録: This study investigated characteristics of people who brush their teeth (including cleaning dentures) 2 times or more a day, which is one of the preventive health behaviors, in terms of the condition of receiving medical treatment for lifestyle- related diseases, such as diabetes mellitus (DM), and higher-level functional capacity. The subjects comprised all 1701 individuals aged 40 years or older living in a village in Nara Prefecture. We distributed a self-administered questionnaire that included questions on oral health behavior, lifestyle (eating, drinking, smoking, exercise behaviors), current health conditions, and the TMIG index as an index of higher-level functional capacity. A total of 1543 individuals (mean age, 64.9 years) who submitted the questionnaire were categorized into four groups: A group (good lifestyle ≧ 3 items and toothbrushing ≧ 2 times a day), B group (good lifestyle ≧ 3 items and toothbrushing < 2 times a day), C group (good lifestyle < 3 items and toothbrushing ≧ 2 times a day), and D group (good lifestyle < 3 items and toothbrushing < 2 times a day). A significant difference in the percentages of those who were under medical treatment for DM was found between the men of A group (3.2%) and B group (7.9%). However, the percentages of those who were under medical treatment for hypertension and hyperlipidemia were similar among all the groups, regardless of gender. Moreover, significant differences in the percentages of subjects who had a perfect "Intellectual Activity" score, which is one of the sublevels of the TMIG index, were found between men in the C group (59.4%) and the D group (48.4%) and between women in the A group (63.4%) and the B group (36.6%). The higher- level functional capacity may be higher among individuals with toothbrushing ≧ 2 times a day, compared with those with toothbrushing < 2 times a day, if the number of good lifestyle items which individuals practice is similar. 2008-04-29T15:00:00Z http://hdl.handle.net/10564/331 タイトル: LOCALIZATION OF PAROTIN SUBUNIT IN THE SALIVARY GLANDS, KIDNEY AND PANCREAS OF THE JAPANESE MONKEY, MACACA FUSCATA 著者: Yahiro, Junko; Miyoshi, Sakuicmro 抄録: Parotin subunit was localized immunohistochemically in the apical region of the duct cells in monkey salivary glands using anti-parotin subunit polyclonal antiserum by both indirect immunofluorescence and indirect immunoperoxidase techniques. Most intense reactivity was observed in the striated duct cells among the duct system cells. In addition, specific immunoreactivity was also detected in the collecting tubules of the kidney and the cells of the pancreatic duct system. It is supposed that parotin subunit plays a role in duct formation. 2008-04-29T15:00:00Z http://hdl.handle.net/10564/330 タイトル: 発毛の再生医学 著者: 王寺, 幸輝; 吉川, 正英; 石坂, 重昭 抄録: 21世紀は｢再生医療｣の時代といわれ,人類の熱き期待が注がれている。近年の細 胞生物学・分子生物学的な解析法の発展により,器官あるいは臓器,個体レベルでの修復機構 が明らかにされつつあり,臨床への応用も行われているほどである。特に人工皮膚などを用い る皮膚科学の分野は,いち早く再生医療を取り入れた例といえよう。しかしながら,皮膚付属 器官である毛髪は,今のところ試験管で再生することができない。それは,複雑な器官(毛包) を形成する詳細なメカニズムが解明されていないためであろう。発毛再生医療に関する最終目 標は,自己の細胞を利用して毛を生み出すことであり,その実現には発毛メカニズムを詳しく 解析することが肝要である。本稿では,これまでに得られている知見を紹介し,さらに著者ら のWntを用いた発毛再生について紹介する。 2008-04-29T15:00:00Z http://hdl.handle.net/10564/329 タイトル: PARANEOPLASTIC ENCEPHALITIS ASSOCIATED WITH OVARJAN TERATOMA: CLINICAL PICTURES AND N-METHYL-D-ASPARTATE RECEPTOR ANTIBODIES 著者: Kataoka, Hiroshi; Ueno, Satoshi 抄録: Background: Recently, a new category of paraneoplastic encephalitis associated with ovarian teratoma has been described and associates with antibodies to NRI/NR2 heteromers of the N-methyl-D-aspartate receptor (NMDAR). Methods: We describe clinical pictures of 26 patients with ovarian teratoma-associated encephalitis (OTE) and the presence of NMDAR antibodies. Results: Clinically, OTE was characterized by the development of acute prominent psy- chiatric symptoms (25 of 26 patients), seizures (19 of 26 patients), central hypoventilation (18 of 26 patients) and involuntary movements (19 of 26 patients). Ventilatory support was required for 84.5 ± 71.8 days on average. The white blood cell count in cerebrospinal fluid was 50.0 ± 56.6/mm3. Twelve patients showed abnormalities on cranial MRI, involving areas such as the temporal regions (seven patients) or brainstem (four patients). In addition to tumor resection, twenty patients received some type of immunotherapy. Twenty-three patients with OTE had neurological improvement, including 14 with full recovery. Immunocytochemical studies showed that cells expressing NR1/NR2 heteromers reacted strongly with the CSF of patients with OTE. Conclusions: Neurologists must be aware of the syndrome described above and evaluate antibodies to NR1/NR2B heteromers of the NMDAR. Detection of these antibodies should prompt the search for an ovarian teratoma and the administration of immunotherapy. 2008-04-29T15:00:00Z