http://hdl.handle.net/10564/1553 2002-12 2026-04-10T15:42:03Z http://hdl.handle.net/10564/88 タイトル: 出生当日に発症した発作性上室性頻拍症にATPが有効であった低出生体重児の1例 著者: 古市, 康子; 吉田, 裕慈; 川口, 千晴; 桑原, 勲; 箕輪, 秀樹; 江國, 豊; 吉岡, 章; 高橋, 幸博; 松村, 正彦 抄録: We report a case in which paroxysmal supraventricular tachycardia (PSVT) in a low-birth-weight newborn, due to atrioventricular nodal re-entry, was successfully treated by intravenous bolus injection of adenosine-5'-triphosphate (ATP). The newborn was a male, born after 36 weeks and 1 day of gestation, weighing 2,204g. One hour after birth, he exhibited tachycardia, at 250 to 270 beats/min. A chest radiogragh revealed cardiomegaly, with a cardiothoracic ratio of 71％. Injection of ATP at a dose of O.3mg/kg resulted in complete cessation of PSVT, with temporary suppression of the sinus node and resumption of normal sinus rhythm within 10 seconds after injection. No serious side effects of ATP injection occurred. Oral digoxin treatment was administered for 10 months after ATP injection, to prevent recurrence of tachycardia. The patient is now 3 years and 2 months old, and there has been no recurrence of tachycardia. 2002-12-30T15:00:00Z http://hdl.handle.net/10564/87 タイトル: 動・静脈血栓形成過程に関する基礎的研究　走査および透過電子顕微鏡による観察 著者: 金, 雄一 抄録: The process of thrombus　formation at arterial and venous endothelial surfaces was examined by scanning electron microscope (SEM) and transmission electron microscope (TEM) in a photochemical occlusion model.The rats were divided into the following 4 groups after the injection of rose bengal:1) control group (n=5)without illumination; 2) group A (n=10) irradiated for 1 min; 3) group B (n=10) for 5 min; 4) group C (n=14) for lO min at cervical artery and vein. As a result, SEM findings showed adhesion of blood platelets and endothelial damage in neither artery nor vein in control and A groups. Plasma membrane damage of endothelial cells (i.e. plasmalemmal pits, the crater-like structure associated with tear between endothelial cells, and decreased number of microvilli) was recognized in arterial wall, but these changes were not observed in vein in group B. Adhesion of blood platelets in addition to endothelial cell membrane obstacle in artery was remarkable by SEM examination and tear between arterial endothelial cells was found by TEM examination in group C. The degree of adhesion of platelets was clearly remarkable in artery compared with vein. In conclusion, endothelial cell membrane injury, tear between endothelial cells and endothelial detachment occur before adhesion of blood platelets and thrombus formation in a blood vessel occlusion model by photochemical reaction. These changes occur significantly earlier in artery than in vein. 2002-12-30T15:00:00Z http://hdl.handle.net/10564/86 タイトル: N-nitr osobis(2-oxopr opyl)amineによるハムスター膵管癌発生に対するウシおよびサメ軟骨水抽出物の影響 著者: 村田, 奈保 抄録: Effects of shark cartilage water-extract (SCE) and bovine cartilage water-extract (BCE) on pancreatic duct carcinogenesis were investigated using a rapid production model for pancreatic duct carcinoma in hamsters, and the following results were obtained. 1. SCE inhibited activities of MMP-2 and MMP-9 but BCE did not in vitro. 2. BCE did not have beneficial effects on chemoprevention of pancreatic carcinomas. 3. No toxic signs, including growth retardation or loss of pancreatic and liver weights, were observed in hamsters treated with BOP followed by SCE. 4. The diet containing O.4％ SCE reduced significantly the numbers of adenocarcinomas and ductallesions． 5. SCE did not affect the BrdU labeling indices of pancreatic ductal lesions. 6. SCE did not affect expression levels of proenzyme form of MMP-2 and MMP-9 and enzyme form of MMP-2 in adenocarcinomas. These results indicate that SCE possesses inhibitory effects on development of pancreatic carcinomas and that SCE may be a candidate of chemopreventive agent for pancreatic carcinomas. 2002-12-30T15:00:00Z http://hdl.handle.net/10564/85 タイトル: 小児の尿路感染症の部位診断における尿中LDHアイソザイム分析の有用性 著者: 松永, 健司; 赤澤, 英樹; 武山, 雅博; 矢本, 陽子 抄録: Clinical differentiation between pyelonephritis and cystitis is often difficult to determine in infants and children. Precise localization of the site of infection is important from a therapeutic and prognostic standpoint in children with urinary tract infection (UTI). The present investigation was undertaken to determine whether or not urinary lactic dehydrogenase (LDH) isoenzyme analysis could be available for differentiation between upper UTI and lower UTI. Fourteen children 2 months to 15 yr of age constituted the subjects for the study. Urinary LDH isoenzyme analyses were performed using cellulose acetate membrane electrophoresis. On the basis of the patterns of urinary LDH isoenzymes, patients were divided into two groups. Of 14 patients, 10 (group I) showed predominant elevations of LDH1 and LDH2 (fast zone pattern) in the urine. In the remaining four (group II), urinary LDH predominantly consisted of LDH4 and LDH5 (slow zone pattern). Clinical findings revealed that body temperatures were significantly higher in group II than in group I. Laboratory findings showed that the serum levels of C-reactive protein (CRP) and urinary levels of β2 microglobulin were slgnificantly higher in group II than in group I. Therefore, patients in group I were compatible with lower UTI and patients in group II with pper UTI. This study shows the urinary LDH isoenzyme analysis to be useful for differentiation between upper UTI and lower UTI in children. 2002-12-30T15:00:00Z