http://hdl.handle.net/10564/1541 2000-12 2026-04-10T15:40:46Z http://hdl.handle.net/10564/643 タイトル: 第121回奈良医学会 : 学会記事 2000-12-30T15:00:00Z http://hdl.handle.net/10564/642 タイトル: 若年発症の虚血性大腸炎4症例における血液凝固系の検討 著者: 梅村, 康義; 水野, 麗子; 八嶌, 功; 吉村, 克敏; 平尾, 和也 抄録: Ischemic colitis is generally considered as a disease of elderly patients with arteriosclelosis. The clinical characteristics and the hemostatic parameters in 4 younger patients with ischemic colitis were analyzed. The patients were 3 females and 1 male, and 25 to 33 years of age. Antithrombin Ⅲ activity, protein C activity, protein S activity and activated protein C ratio were within normal limits, and anticardiolipinβ2 glycoprotein Ⅰ antibody was not detected. There was no laboratory evidence of thrombophilia in these patients. Constipation might be related to the onset of ischemic colitis in 2 of the patients. 2000-12-30T15:00:00Z http://hdl.handle.net/10564/641 タイトル: 後腹膜腔に発生したganglioneuromaの1例 著者: 望月, 裕司; 山本, 雅司; 岸野, 辰樹; 谷, 善啓; 雄谷, 剛士; 大園, 誠一郎; 平尾, 佳彦; 壬生, 寿一; 明山, 達哉; 森田, 昇 抄録: We report a 30-year-old male patient with retroperitoneal ganglioneuroma. He was referred to our hospital with the complaint of right flank pain. Abdominal US, CT and MRI showed a right retroperitoneal tumor. He underwent total resection of the tumor with right adrenal gland. The pathological diagnosis was ganglioneuroma. Pathogenesis and management of this rare condition are discussed. 2000-12-30T15:00:00Z http://hdl.handle.net/10564/640 タイトル: Fischer 344系ラットにおけるコリン欠乏およびコリン添加アミノ酸食の長期投与による毒性と発癌性 著者: 安藤, 信明 抄録: The present study assessed toxicologic and carcinogenic effects of a long- term administration of semisynthetic, choline-deficient, L-amino acid-defined (CDAA) and choline-supplemented, L-amino acid-defined (CSAA) diets in Fischer 344 (F344) rats. Male and female F344 rats, 5 weeks old, were fed the CDAA or CSAA diet or a conven- tional laboratory chow, and sacrificed at the end of week 52 and by the end of week 104. All organs were excised on sacrifice and histologically examined. The following results were obtained. 1. Hepatocellular carcinomas (HCCs) were induced with high incidence in male rats fed the CDAA diet. HCC was induced in the background presence of fatty liver and cirrhosis, through a progression sequence starting from eosinophilic altered hepatocellular focus, then hepatocellular adenoma, and carcinoma-in-adenoma. 2. HCCs were also induced in female rats fed the CDAA diet with the lower incidence than in male case. 3. The CDAA diet suppressed the induction of testicular interstitial cell tumors and pituitary adenomas in males. Both of the CDAA and CSAA diets promoted the induction of mammary fibroadenomas in females. 4. The CDAA diet induced intestinal lacteal dilatations in both genders, and promoted the induction of nephropathies in both genders and nephrocalcinoses in males. Both of the CDAA and CSAA diets promoted the induction of pancreatic altered acinar cell foci plus acinar cell hyperplasias, forestomach squamous cell hyperplasias and thyroidal C-cell hyperplasias in both genders and nephrocalcinoses in females. It is thus indicated that the CDAA diet is hepatocarcinogenic toward both of male and female F 344 rats and modifies the induction of various spontaneous lesions. In addition, the CSAA diet can also modify the induction of some spontaneous lesions. Assessments for the detailed machanisms underlying not only hepatocarcinogenesis but also modification of the induction of various other lesions are warranted in rats fed the CDAA diet. 2000-12-30T15:00:00Z