http://hdl.handle.net/10564/1496 1995-10 2026-04-10T15:44:12Z http://hdl.handle.net/10564/2936 タイトル: N-butyl-N-(4-hydroxybutyl) nitrosamineによるラット膀胱発癌における細胞増殖の解析 著者: 岡本, 新司 抄録: Histopathological examination, flowcytometry (FCM) study and proliferating cel1 nuclear antigen (PCNA) analysis were serially performed during the induction of carcinogenesis by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in the rat bladder, which is known to be an experimental model of human non-invasive papil1ary bladder cancer. Histological malignancy of the induced tumors was compared with the degree of cel1 proliferation by these three methods. FCM analysis revealed substantial differences of DNA change in bladder epithelial cel1s between the 4-week and 8-week treatment groups. These findings coincided with the changes observed in the histopathological examination concurrently performed. In the analysis of ploidies, tetraploid did not appear in the bladder of rats treated with BBN for 4 weeks. In PCNA analysis of epithelial cel1s in BBN-induced rat bladder carcinoma, PCNA-positive cel1sin the carcinoma increased with the severity of histopathological change. In addition, the PCNA index tended to be higher in the bladder of rats treated with BBN, which appeared to be histopathological1y normal. These findings suggest that the PCNA index serves as one useful parameter to predict the progression and proliferation of bladder carcinoma. 1995-10-30T15:00:00Z http://hdl.handle.net/10564/2935 タイトル: 精神分裂病における退屈についての一考察 (外的刺激に際しての反応並びに精神症状評価) 著者: 松岡, 出 抄録: Psychopathological aspects were studied through investigations of asking schizophrenic inpatients about their views related to boredom. Boredom has seldom been researched in spite of being an important phenomenon in understanding schizophrenia. This paper suggests that schizophrenic patients, especially chronic patients, are often satisfied with monotonous circumstances. External stimulus, even though unexpected, does not easily alter behaviour patterns. 1995-10-30T15:00:00Z http://hdl.handle.net/10564/2934 タイトル: 皮膚電気活動、主観的気分変化、精神症状、治療効果に対する向精神薬の影響の研究 : 単回、点滴静注による試み 著者: 山岡, 一衛 抄録: The aim of this study was to examine the possibility that skin conductance level (SCL) and a patient's subjective mood change during intravenous drip injection of psychopharmaca could predict the results of, or response to, phycopharmacotherapy. Sixty-six patients with depression, 42 with neurosis, 25 with schizophrenia and 8 with other psychiatric disorders were investigated on SCL, subjective mood change, and score of Brief Psychiatric Rating Scale (BPRS) during intravenous drip injection of sulpiride or other psychopharmaca. Improved subjective mood changes were significantly correlated to decreased SCL and were also significantly correlated to results of treatment in 1 month and 3 months. For depressive patients a criterion of SCL<4.0μS and improved subjective mood change might be a good predictor of favorable results of, or favorable response to, psychopharmacotherapy. 1995-10-30T15:00:00Z http://hdl.handle.net/10564/2933 タイトル: 特別養護老人ホーム新規入所者に対する精神医学的介護に関する縦断的研究 著者: 三宅, 雅一 抄録: Studies on psychiatric issues of 244 consecutive new residents in a nursing home were made prospectively and longitudinally. Psychiatric diagnoses, psychotic symptoms, behavioral problems, score with Hasegawa's dementia rating scale, and activity of daily living (ADL) were investigated. The prevalence rate of dementia was 88.9% (Alzheimer type, 22.5% : vascular type, 45.5%). 77.9% of the total sample had psychotic symptoms, and 44.3% had behavioral problems. In cases of Alzheimer type dementia, the severity of dementia and the number of behavioral problems significantly increased with time course, while these did not change significantly in cases of vascular dementia. 1995-10-30T15:00:00Z