1991-04 http://hdl.handle.net/10564/1987 2026-04-10T15:41:18Z 2026-04-10T15:41:18Z 吉岡, 稔 植村, 和嘉 山本, 伸介 吉田, 精司 土田, 雅久 板橋, 正憲 藪内, 久 江口, 陽子 寺田, 貴子 杉村, 正仁 http://hdl.handle.net/10564/1996 2017-05-29T06:07:55Z 1991-04-29T15:00:00Z

タイトル: 当科における過去8年間の顎顔面骨骨折の臨床統計的観察 著者: 吉岡, 稔; 植村, 和嘉; 山本, 伸介; 吉田, 精司; 土田, 雅久; 板橋, 正憲; 藪内, 久; 江口, 陽子; 寺田, 貴子; 杉村, 正仁 抄録: Clinico-statistical analysis was made in 537 patients with maxillo-facial fracture referred to the Department of Oral and Maxillo-facial Surgery, Nara Medical University Hospital, from October, 1981 to September, 1989. The following results were obtained : 1. In an investigation of frequencies according to age, the two most common age groups were those in their teens and twenties. The ratio of males to females was 2.5:1. 2. Traffic accidents were the most frequent causes. Then falling and violence followed. About 70% of the patients came to our department within 7 days after injuries. 3. The common sites of the fractures were the mandible alone in 57.7% of cases, followed by zygomatic fracture. And 14 cases were found in the combined mandible, maxilla and zygoma. 4. Open reduction was applied to 48.9% of cases in mandibular fracture, and 41.6% in zygomatic fracture.

1991-04-29T15:00:00Z 三上, 貞昭 森井, 直之 根津, 智子 山下, 千賀子 新家, 直子 寺本, 好弘 西村, 拓也 中, 宏之 http://hdl.handle.net/10564/1995 2017-05-29T06:07:55Z 1991-04-29T15:00:00Z

タイトル: 21-ハイドロキシラーゼ欠損症(塩喪失型)1家系における出生前診断の試み 著者: 三上, 貞昭; 森井, 直之; 根津, 智子; 山下, 千賀子; 新家, 直子; 寺本, 好弘; 西村, 拓也; 中, 宏之 抄録: A prenatal diagnosis was performed in a family with salt-wasting type of 21-hydroxylase deficiency (21-OHD). A trial of DNA diagnosis in the family, including a patient, did not reveal informative data when DNAs were restricted with TaqⅠ and hybridized with pC21/3c probe. The level of 17-OHP in the amnion was within a normal range. A girl was born without clinical symptoms. One HLA haplotype which was detected in the patient was inherited from the father. With a view to increasing the number of Japanese families which are proceeded to prenatal DNA diagnosis, it is expected that a beneficial combination with a small number of intragenic RFLPs and/or extragenic RFLPs close to the gene will be established and widely used. Hereafter, prenatal diagnosis in early pregnany will be important for families with 21-OHD.

1991-04-29T15:00:00Z 友田, 恒一 阿児, 博文 濱田, 薫 長, 澄人 鴻池, 義純 佐々木, 秀明 成田, 亘啓 http://hdl.handle.net/10564/1994 2017-05-29T06:07:55Z 1991-04-29T15:00:00Z

タイトル: パラインフルエンザ1型の抗体価の上昇を伴い特異な胸部X線所見を呈した器質化肺炎の1例 著者: 友田, 恒一; 阿児, 博文; 濱田, 薫; 長, 澄人; 鴻池, 義純; 佐々木, 秀明; 成田, 亘啓 抄録: A case of organizing pneumonia is reported. A 74-year-old man was admitted to our hospital complaining of general fatigue and dyspnea of 2 months' duration. Chest roentogenogram on admission revealed interstitial shadow in the left upper-to-middle lung field. Thereafter the chest x-ray shadow showed migration to the left lower lung and right middle lung fields, and superimposition with volume loss of the left lower lung. No pathogenic microorganisms were detected from sputum and throat swabs. No organisms were detected in the blood. Therefore he was set to conservative therapy alone. The antibody titer of parainfluenza virus type 1, initially 1:64, increased to 1:2048 just before bronchoscopy. The histopathological findings of TBLB showed that alveolar spaces were filled with organizing process and that septum was thickened slightly with edema and fibrosis, whose findings were compatible for organizing pneumonia. Prednisolone was begun and marked improvement of chest x-ray findings and clinical symptoms were achieved immediately. But recurrence was seen twice during withdrawal of steroids within six months and he died suddenly of unknown cause. Autopsy could not be performed. Although the pathogenesis of organizing pneumonia has not been determined yet, this case was of interest in two points : first, the chest x-ray finding was thought to be interstitial rather than alveolar process ; and second, antibody of parainfluenza virus type 1 fluctuated, suggesting some pathogenetic relation.

1991-04-29T15:00:00Z 山本, 一彦 http://hdl.handle.net/10564/1993 2017-05-29T06:07:54Z 1991-04-29T15:00:00Z

タイトル: ラットの生体内で生成されたN-nitrosobis(2-hydroxypropyl)amineの発癌性に関する研究 著者: 山本, 一彦 抄録: Carcinogenic activity of endogenously synthesized N-nitrosobis(2-hydroxypropyl)amine (BHP) from bis(2-hydroxypropyl)amine (BHPA) and tris(2-hydroxypropyl)amine (THPA) in the presence of sodium nitrite (SN) was investigated in male Wistar rats. The following results were obtained. 1) The synthesis of BHP from BHPA and THPA in the presence of SN was demonstrated in vitro and in vivo in the preliminary experiment and also confirmed by the urinary excretion of BHP in rats treated with 1% BHPA and 2% THPA in diet together with 0.3% SN in drinking water. 2) Tumors in nasal cavity and lung were induced in rats treated with 1% BHPA in diet together with 0.3% SN in drinking water for 94 weeks, the incidences of which reached 74% and 58%, respectively. However, no tumors were found in the target organs of BHP in rats treated with 2% THPA in diet and 0.3% SN in drinking water for 102 weeks. 3) The initiation activity for liver by endogenously synthesized BHP was observed in rats treated with 1% BHPA in diet together with 0.15% and 0.3% SN in drinking water by the quantitative analysis of glutathione S-transferase placental form (GST-P)-positive foci but was not observed in rats treated with 2% THPA in diet together with 0.15% and 0.3% SN in drinking water. These results indicate that endogenously synthesized BHP has a carcinogenic activity similar to that of exogenously administered BHP, and that BHPA is more important as the precursor for endogenous BHP synthesis. Since the precursors of nitrosamines are widely distributed in the environment, endogenously synthesized nitrosamines may play an important role in the development of human cancer.

1991-04-29T15:00:00Z