1993-02 http://hdl.handle.net/10564/1843 2026-04-09T03:45:14Z 2026-04-09T03:45:14Z 松為, 泰介 金泉, 年郁 朴, 秀一 石川, 博文 清水, 良祐 河嶌, 勝 中野, 博重 http://hdl.handle.net/10564/1849 2017-05-29T06:07:48Z 1993-02-27T15:00:00Z

タイトル: アンケート調査による幽門保存胃切除術の長期遠隔成績 著者: 松為, 泰介; 金泉, 年郁; 朴, 秀一; 石川, 博文; 清水, 良祐; 河嶌, 勝; 中野, 博重 抄録: A long-term follow-up study using a questionnaire was conducted in order to assess clinical results of pylorus-preserving gastrectomy (PPG). Of 54 patients who underwent PPG, 45 patients followed for more than seven years were analyzed in the late postoperative state. These patients were compared with patients who underwent Billroth Ⅰ resection (BⅠ) by their　responses to datailed questionnaires.　Through the long-term follow-up results, PPG was found to be similar to BⅠ with regard to social life, meal intake, sense of abdominal pressure, heartburn sensation, recurrence rate and satisfaction rate, but superior to BⅠ with regard to gain of body weight, nausea, diarrhea and symptoms of dumping. The results suggest that PPG is worthy of trial as a surgical treatment of gastric ulcer.

1993-02-27T15:00:00Z 上辻, 秀和 山下, 隆司 中島, 充 岡島, 馨 松永, 健司 河原, 信吾 http://hdl.handle.net/10564/1848 2017-05-29T06:07:47Z 1993-02-27T15:00:00Z

タイトル: アミノヌクレオシド腎症における腎糸球体および血小板膜陰性荷電の変化 著者: 上辻, 秀和; 山下, 隆司; 中島, 充; 岡島, 馨; 松永, 健司; 河原, 信吾 抄録: In aminonucleoside nephrosis (AN), which can be regarded as an experimental model of minimal change nephrotic syndrome (MCNS), ultrastructural alteration of glomerular anionic sites were studied using polyetyleneimine (PEI) as a cationic probe, and correlated with the change of platelet membrane negative charge. In control rats, PEI was seen in epithelial cell surface and in both lamina rara externa and lamina rara interna. On the other hand, AN rats, showed a loss of polyanion on the epithelial surface associated with foot process fusion and a reduction of anionic sites within glomerular basement membrane. The degree of anionic sites correlated with proteinuria. The negative charge of pletelet membrane also decreased in AN rats and correlated with a loss of glomerular anionic sites. However, there was no remarkable change in platelet morphological findings on electron microscopy. These findings may provide useful information on platelet function in pediatric MCNS.

1993-02-27T15:00:00Z 金内, 雅夫 紀川, 伊敏 西岡, 久之 森本, 真弓 石井, 健司 川野, 貴弘 石原, 京子 中島, 靖夫 西浦, 公章 土肥, 和紘 石川, 兵衞 http://hdl.handle.net/10564/1847 2017-05-29T06:08:02Z 1993-02-27T15:00:00Z

タイトル: 糖尿病における動脈硬化性血管障害の臨床的特徴 著者: 金内, 雅夫; 紀川, 伊敏; 西岡, 久之; 森本, 真弓; 石井, 健司; 川野, 貴弘; 石原, 京子; 中島, 靖夫; 西浦, 公章; 土肥, 和紘; 石川, 兵衞 抄録: The major risk factors of diabetic macroangiopathy and the associations between macroangiopathy and microangiopathy were examined in a cross-sectional study by multi-factorial analysis. The study group comprised 544 diabetics admitted between 1982 and 1991, of whom 350 were fully available for analysis. Variables used in this analysis included current age, age at onset, diabetes duration, obesity, hypertension, hyperlipidemia, ischemic heart disease (IHD), cerebro-vascular disease (CVD), arteriosclerosis obliterans (ASO), nephropathy, retinopathy and treatment modality. Results were as follows : (1) IHD was closely associated with onset at 50s and 60s, disease duration of 5 to 9 years, and oral agent ; (2) CVD was closely associated with aging, disease duration of 10 to 14 years, simple retinopathy, and oral agent ; (3) ASO was closely associated with disease duration of more than 15 years and persistent proteinuria.

1993-02-27T15:00:00Z Satoh, Hiroyasu Matsui, Kazunori Nakatani, Toshiaki Narushima, Itaru Nakashima, Toshikatsu http://hdl.handle.net/10564/1846 2017-06-11T23:20:26Z 1993-02-27T15:00:00Z

タイトル: USE-DEPENDENT BLOCK AND RECOVERY OF NA⁺ CHANNELS BY CLASS IC ANTIARRHYTHMIC DRUGS (FLECAINIDE AND ETHACIZIN) IN CANINE VENTRICULAR MUSCLE 著者: Satoh, Hiroyasu; Matsui, Kazunori; Nakatani, Toshiaki; Narushima, Itaru; Nakashima, Toshikatsu 抄録: Electrophysiological effects of flecainide and ethacizin (class Ic antiarrhythmic drugs) were examined using conventional microelectrode techniques. Flecainide significantly depressed the maximum rate of depolarization (⩒max) at 3x10⁻⁶M, and depolarized the resting potential (RP) at 10⁻⁵M, in a concentration-dependent manner. Ethacizin depressed ⩒max at 10⁻⁶M, and depolarized RP at 10⁻⁵M, significantly. However, both drugs did not affect the effective refractory period (ERP) nor the action potential duration (75% repolarization, APD₇₅). Both also had no effect on the action potential amplitude (APA). On the other hand, the drugs caused a use (or rate)-dependent block of ⩒max, and their time constants of onset of inhibition (at 3 Hz) were slow ; 6.3±1.2　msec (n=10) in the presence of flecainide (10⁻⁵M), and 6.0±1.6 msec (n=6) in the presence of ethacizin (10⁻⁵M). The time constants of the recovery were also so late : 12.2±2.5 sec (n=3) for flecainide (10⁻⁵M), and 27.1±13.3 sec (n=3) for ethacizin (2x10⁻⁶M), These results indicate that both antiarrhythmic drugs, flecainide and ethacizin, have no effect on APD₇₅ and ERP, but possess the characteristics for very slow kinetics of the use-dependent block and the recovery for fast Na⁺ channels of cardiac muscles. Ethacizin produces slower kinetics for the Na⁺ channels than flecainide.

1993-02-27T15:00:00Z