1993-04 http://hdl.handle.net/10564/1830 2026-04-10T15:44:08Z 2026-04-10T15:44:08Z 島, 正幸 森本, 広之 箕輪, 秀樹 山下, 隆司 上辻, 秀和 http://hdl.handle.net/10564/1842 2017-05-29T06:07:49Z 1993-04-29T15:00:00Z

タイトル: 特発性高カルシウム尿症の2例 著者: 島, 正幸; 森本, 広之; 箕輪, 秀樹; 山下, 隆司; 上辻, 秀和 抄録: Idiopathic hypercalciuria (IH) is defined as an abnormally high urine calcium excretion rate without original diseases that cause hypercalciuria such as hyperparathyroidism, renal tubular acidosis, vitamin D intoxication, or Cushing syndrome. IH is well-known as one of the causes of urolithiasis in adults. IH has been made much account of as the cause of hematuria in childhood, since Stapleton and his colleague reported hypercalciuria in children with hematuria in 1984. Two girls who had asymptomatic hematuria were diagnosed as IH by the measurement of 24-hour urinary calcium excretion after the screening of measuring the calcium/creatinine concentration ratio in early morning urine. Both cases were judged as absorptive idiopathic hypercalciuria by means of calcium-loading test. They were treated by only mild restriction of salt or calcium and have had no gross hematuria episode after treatment.

1993-04-29T15:00:00Z 大門, 位守 http://hdl.handle.net/10564/1841 2017-05-29T06:07:49Z 1993-04-29T15:00:00Z

タイトル: 大和高原三村の食生活構造の特性と健診情報との関連性に関する研究 著者: 大門, 位守 抄録: To clarify the characteristics of eating habits among the residents of Yamato-Kogen district, we conducted a principal component analysis of food frequency questionnaire (consisting of 14 items) obtained from the people participating in communitybased mass examinations. The examinations were performed is the district under stuby between July and September, 1992. Their data were compared with data for the control group ; the families of students studying the science of nutrition in college at Nara city. Eigen values, contribution ratios and loading factors were calculated from correlation matrix among 14 items. As the first principal component, the items of Q10 (food cooked with oil), Q7 (boiled fish pastes), Q5 (fishes), Q3 (eggs), Q13 (tsukudani), Q11 (misosoup) were extracted, and as the second one those of Q1 (cooked paddy rice), Q13, Q6 (salted, semidried, split fishes) and Q12 (tsukemono) were extracted. The first principal component was considered to represent a shift from conventional foods in the countryside, and the second one conventional village-type foods. Principal shores of the first to the third principal components were yielded individually using loading factors for each subgroup classified by gender and village. Distribution patterns of two of those components indicated that differences in eating were found not only between men and women but also within the village under study. The distribution pattern found also clearly identifies the persons whose eating habits deviated nutritionally. For the same subjects a multiple regression analysis was done on all kinds of laboratory data and 14 items of food frequency questionnaire. The results revealed the existence of association between eating habits and laboratory data.

1993-04-29T15:00:00Z 原田, 七寛 http://hdl.handle.net/10564/1840 2017-06-11T23:20:26Z 1993-04-29T15:00:00Z

タイトル: Corynebacterium kutscheriの抗腫瘍性に関する研究 著者: 原田, 七寛 抄録: The antitumor effect of Corynebacterium kutscheri was evaluated in mice by the administration of formalin-killed whole cell (FK-CK) or subcellular fraction named CK・m (mitogen derived from C. kutscheri). In these studies, two systems of mouse vs tumor cell (outbred ddY vs Ehrlich ascites carcinoma cell, inbred CDF₁ vs P388 leukemia cell) were used. Treatment of mice in the dose range of greater than 10⁶ bacterial cells or 20 μg of CK・m per mouse conferred substantial protection on both mice. The enhanced cytotoxicity of peritoneal exudate cells played a leading role in the initial phase of antitumor activity. The Winn assay disclosed that antitumor activity was attributable to nonadherent splenocytes whose activity was impaired by treatment with anti-T cell antibody and complement. The fact that the generation of effector cells paralleled that of the delayed-type hypersensitivity to this bacterium may suggest that the antitumor activity of C. kutscheri is mediated in part by T cell. The isolation and characterization of biological activities of the active component of C. kutscheri were attempted. The antitumor activity was confined to the subcellular particle fraction of this organism and associated with a molecule of glycoprotein nature (38,000 Dalton) isolated from this fraction by affinity chromatography with Concanavalin A-Sepharose 4B. This substance exerted mitogenic effect on C3H/HeJ splenocytes and T cells and further exhibited antitumor activity on P388 leukemia cell in CDF₁ mice. The Winn assay disclosed that the antitumor activity induced by this material was dependent on L3T4 T cells. Furthermore, both the mitogenic and antitumor activity of this moiety were resistant to heating at 100℃ for 30 min or RNase digestion, but sensitive to trypsin digestion, low or high pH. These results indicate that the antitumor activity of C. kutscheri is attributable to the heat-stable glycoprotein moiety which can directly stimulate T cells and macrophages.

1993-04-29T15:00:00Z 河原, 信吾 http://hdl.handle.net/10564/1839 2017-05-29T06:07:47Z 1993-04-29T15:00:00Z

タイトル: 小児IgA腎症ならびに紫斑病性腎炎における糸球体内細胞外基質成分の免疫電顕的研究 著者: 河原, 信吾 抄録: Immunoelectron microscopic investigation for extracellular matrix (ECM) components was carried out in renal biopsy tissues from 31 children with IgA nephropathy and 22 children with Henoch-Schönlein purpura nephritis (HSPN), as well as 5 normal adults. Immunogold labeling, using antisera against Type Ⅰ, Ⅲ, Ⅳ, Ⅴ, Ⅵ collagens, laminin (Lam), fibronectin (FN), and vitronectin (VN), in normal glomeruli revealed that FN was found restrictively in mesangial matrix (MM), Lam throughout glomerular basement membrane (GBM), Type Ⅳ collagen both in MM and lamina rara interna of GBM, and Type Ⅴ collagen in podocytes in minor amounts. The immunoreactivity of Type Ⅰ, Ⅲ, Ⅵ collagens and VN was not seen in normal glomeruli. In children with mild mesangial proliferation of IgA nephropathy and HSPN, extension of FN labeling over GBM and VN distribution within mesangial electron-dense deposit (EDD)s were observed. During the progression of mesangial proliferation, the antigenic sites of Type Ⅰ, Ⅲ, Ⅴ, Ⅵ collagens and FN appeared in MM or EDDs, and the labeling intensity of Type Ⅳ collagen and FN was gradually increased in MM or GBM. In the advanced stage of sclerotic glomeruli, the distribution of Type Ⅳ collagen and Lam remained, though that of Type Ⅰ, Ⅲ, Ⅴ, Ⅵ collagens, FN, and VN was reduced. These findings suggest that ECM components such as Type Ⅰ, Ⅲ, Ⅳ collagens, FN, and VN could play an important role in MM expansion, and that the deposition of these components is closely related to the progress of glomerulosclerosis.

1993-04-29T15:00:00Z