DSpace コレクション: 2008-122008-12http://hdl.handle.net/10564/15272026-04-10T15:42:23Z2026-04-10T15:42:23Z第128回奈良医学会 : 学会記事http://hdl.handle.net/10564/9192017-06-11T23:20:26Z2008-12-30T15:00:00Zタイトル: 第128回奈良医学会 : 学会記事2008-12-30T15:00:00Z食道異所性皮脂腺の2例榎本, 潤夏中峯, 寛和笠井, 孝彦榎本, 泰典武田, 麻衣子高野, 将人森田, 剛平野々村, 昭孝野口, 隆一福井, 博更屋, 勉http://hdl.handle.net/10564/9182020-08-18T02:20:22Z2008-12-30T15:00:00Zタイトル: 食道異所性皮脂腺の2例
著者: 榎本, 潤夏; 中峯, 寛和; 笠井, 孝彦; 榎本, 泰典; 武田, 麻衣子; 高野, 将人; 森田, 剛平; 野々村, 昭孝; 野口, 隆一; 福井, 博; 更屋, 勉
抄録: Two cases of heterotopic sebaceous glands in the esophagus, found in a
71-year-old male and a 50-year-old female patient, are reported. In both cases,
endoscopic examination revealed multiple yellowish plaques sized 1 to 3mm in diameter
in the esophagus, which were initially interpreted as probable candida infection,
xanthoma, or glycogenic acanthosis. Histological examinations of biopsy specimens
showed clusters of clear cells in the squamous cell epithelium. They had pale cytoplasm
with centrally located small nuclei and closely resembled sebaceous glands of the skin,
and were histologically interpreted as heterotopic sebaceous glands of the esophagus.
Along with recent advances in endoscopic technique, reported cases of heterotopic
sebaceous glands in the esophagus are increasing. However, the histogenesis of
heterotopic sebaceous glands in the esophagus has not been well established and remains
to be established. The present report concerns two cases of heterotopic esophageal
sebaceous glands accompanied by some immunohistochemical studies.2008-12-30T15:00:00Z高齢膀胱癌患者に対する膀胱全摘除術に関する検討細川, 幸成星山, 文明桑田, 真臣熊本, 廣実林, 美樹藤本, 清秀平尾, 佳彦http://hdl.handle.net/10564/9172017-05-29T06:06:56Z2008-12-30T15:00:00Zタイトル: 高齢膀胱癌患者に対する膀胱全摘除術に関する検討
著者: 細川, 幸成; 星山, 文明; 桑田, 真臣; 熊本, 廣実; 林, 美樹; 藤本, 清秀; 平尾, 佳彦
抄録: Purpose : Bladder carcinoma often occurs in the elderly. We compared the clinical results
of radical cystectomy between elder and younger patients.
Materials and Methods : We retrospectively reviewed the records of 59 patients who
underwent radical cystectomy for bladder carcinoma between 1993 and 2006. Two groups
were compared:≦75 years old (n=49) and ＞75 years old (n=10). Overall survival and
disease specific survival were evaluated using Kaplan-Meier methods and a multivariate
Cox model.
Results : There were no significant differences in blood loss and transfusion volume
during the operation. However, the operative time in the younger patients was longer
than in the elderly patients (p＜0.01). The rate of complication in the elderly patients was
not different from that in the younger patients (p=0.86). The 5-year disease specific
survival rates for patients ≦75 and ＞75 years old were 80.1% and 42.5%, respectively
(p＜0.01). The elderly did not receive adjuvant chemotherapy.
Conclusions : In the current series, almost all the elderly patients tolerated radical
cystectomy compared with the younger patients. Further work is needed to determine
indications for radical cystectomy and to develop strategies to improve cancer control in
elderly patients.2008-12-30T15:00:00Z胚性幹細胞(ES細胞)からの3胚葉分化久保, 篤史http://hdl.handle.net/10564/9162017-05-29T06:06:56Z2008-12-30T15:00:00Zタイトル: 胚性幹細胞(ES細胞)からの3胚葉分化
著者: 久保, 篤史
抄録: 近年,ヒト胚性幹細胞(ES細胞)からの様々な細胞への分化の報告がなされてお
り,骨髄細胞由来の問葉系幹細胞なども樹立されて,再生医療への応用が期待されている.さ
らに最近では,ヒト皮膚線維芽細胞からヒト人工多能性幹細胞(ips細胞)などの樹立もあり,倫
理的問題がなく,拒絶のない夢の再生医療にさらなる注目がなされている.これらの未分化幹
細胞から臓器特異的な細胞への分化は,胎児での胚形成と非常に似た分化段階を有しているこ
とが分かっており,まず第1段階として,幹細胞からの3胚葉分化のメカニズムの解明が非常
に重要である.これまで,ES細胞から外胚葉,中胚葉細胞への報告は多数あったが,内胚葉細
胞への分化についての報告はなかった.我々は,無血清培地条件下でアクチビンによる内胚葉
分化の方法を確立し,報告している.本稿では,我々のES細胞からの3胚葉分化についての研
究成果と最近の知見について述べてみたい.2008-12-30T15:00:00Z