1996-12 http://hdl.handle.net/10564/1513 2026-04-10T15:42:24Z 2026-04-10T15:42:24Z http://hdl.handle.net/10564/772 2017-06-11T23:20:26Z 1996-12-30T15:00:00Z

タイトル: 第117回奈良医学会 : 学会記事

1996-12-30T15:00:00Z 山下, 隆司 http://hdl.handle.net/10564/771 2017-06-11T23:20:26Z 1996-12-30T15:00:00Z

タイトル: 小児IgA腎症の糸球体内 Cross-linked fibrin に関する研究 : 第二報 抗凝固療法による Cross-linked fibrin の変化 著者: 山下, 隆司 抄録: The changes of intraglomerular deposits of cross-linked fibrin after the combined therapy (prednisolone, warfarin and dipyridamole) in children with IgA ne- phropathy, who had severe proteinuria, mesangial proliferation and crescents, were inves- tigated. Twenty children were divided into two groups by their response to the combined therapy at six months after administration, as follows : Effective Group, patients with a decrease in proteinuria and hematuria and Ineffective Group, patients without a decrease in proteinuria and hematuria. There were no significant differences between Effective Group and Ineffective Group in activity index and chronicity index at the first biopsy, but Effective Group patients showed a deposition of cross-linked fibrin on the glomeruli of the first biopsy specimen (p＜0.05). In Effective Group patients, crescents, cell infiltration, activity index, segmental sclerosis, tubular aitrophy and chronicity index had significantly decreased in the rebiopsy specimen (p＜0.05), whereas deposition of cross-linked fibrin remained unchanged. These findings suggest that the deposition of cross-linked fibrin on the first biopsy speci- men may predict the response to the combined therapy after six months, but there was no decrease in cross-linked fibrin after the combined therapy.

1996-12-30T15:00:00Z 長尾美津男 藪内裕也 仲川恵三 島田健太郎 http://hdl.handle.net/10564/770 2017-05-29T06:06:59Z 1996-12-30T15:00:00Z

タイトル: 大量下血を繰り返した小腸粘膜下海綿状血管腫の一例 著者: 長尾美津男; 藪内裕也; 仲川恵三; 島田健太郎 抄録: We present a case of hemangioma of the small intestine with repeated massive bleeding. A 57-year-old woman repeated massive bleeding three times from February 1993 to July 1994. In the meantime endoscopic examination, enterography and abdominal angiography were performed and we detected an abnormal lesion in enterogra- phy. But we could not diagnose the cause of bleeding because the abnormal lesion was not recognised in angiography. At the third incidence of bleeding we performed an emergency operation. At the laparotomy a dark red, flat and soft tumor was found in the small intestine at 100 cm's distance from Treits ligament and a partial resection of jejunum was performed. By the microangiography of the resected speciemen and histological examina- tion, the tumor was diagnosed as a cavernous hemangioma of the small intestine. Tech- niques for efficient examination of the small intestine are not well established as compared to the other areas of the digestive tract. Therefore in this case we detected the abnormal lesion with enterography but we could not recognise any abnormal findings in angiography. As a result we were able to detect the hemangioma of the small intestine for the first time during the operation. The intestinal hemangioma is a rare case and it is difficult to diagnose the cause of bleeding as intestinal hemangioma without an abnormal finding in angiography. It is nesessary that we suspect that massive bleeding may be due to intestinal hemangioma when we cannot presume the origin of massive bleeding.

1996-12-30T15:00:00Z 仲谷, 宗裕 http://hdl.handle.net/10564/769 2017-05-29T06:06:59Z 1996-12-30T15:00:00Z

タイトル: 肺結核症患者におけるサイトカイン産生能に関する研究 : 第2報 末梢血単核球サイトカイン産生能の検討 著者: 仲谷, 宗裕 抄録: Interferon-γ (IFN-γ) and interleukin-10 (IL-10)-producing ability of peripheral blood mononuclear cells (PBMC) obtained from patients with active pulmonary tuberculosis (N=17) and healthy controls (N=14) were assessed upon stimulation with purified protein derivatives (PPD). Blood was extracted on two occasions from each patient with active pulmonary tubercu- losis without any underlying diseases ; before the initiation of anti-tuberculous chemother- apy and 2 months later from the negative conversion of Mycobacterium tuberculosis in sputum culture. Adherent cells and non-adherent cells were prepared from PBMC. IFN-γ and IL-10 level were measured by ELISA in culture supernatants of adherent cells and non-adherent cells stimulated with PPD. Non-adherent cells obtained on admission produced IFN-γ significantly higher than did the cells of healthy controls (P＜0.001). Elevated production of IFN-γ by non-adherent cells obtained on admission was reduced after anti-tuberculous treatment (P＜0.03). IL-10 production by non-adherent cells of the patients was lower than that by the cells of healthy controls, although the difference was not statistically significant. IL-10 production by non-adherent cells obtained on admission was significantly correlat- ed with the duration of culture positive in the sputum (P＜0.05). IL-10 level produced by adherent cells from nutritionally normal patients was significant- ly higher than that of healthy controls(P＜0.05), and elevated IL-10 level was significantly reduced aft er therapy (P＜0.05). In the normonourished patients, the duration of culture positive in the sputum of patients with higher level of IL-10 of non-adherent cells (N=5) was significantly longer than that of patients with reduced IL-10 levels after therapy. These results suggests that IL-10 produced by monocytes may diminish the TH 1 responses of patients with pulmonary tuberculosis.

1996-12-30T15:00:00Z